Corrigendum to Effect of Stratum Corneum Heterogeneity, Anisotropy, Asymmetry and Follicular Pathway on Transdermal Penetration

Details

• Personal Author:
  Barbero, Ana M. ; Frasch, H. Fredrick
• Description:
  The impact of the complex structure of the stratum corneum on transdermal penetration is not yet fully described by existing models. A quantitative and thorough study of skin permeation is essential for chemical exposure assessment and transdermal delivery of drugs. The objective of this study is to analyze the effects of heterogeneity, anisotropy, asymmetry, follicular diffusion, and location of the main barrier of diffusion on percutaneous permeation. In the current study, the solution of the transient diffusion through a two-dimensional-anisotropic brick-and-mortar geometry of the stratum corneum is obtained using the commercial finite element program COMSOL Multiphysics. First, analytical solutions of an equivalent multilayer geometry are used to determine whether the lipids or corneocytes constitute the main permeation barrier. Also these analytical solutions are applied for validations of the finite element solutions. Three illustrative compounds are analyzed in these sections: diethyl phthalate, caffeine and nicotine. Then, asymmetry with depth and follicular diffusion are studied using caffeine as an illustrative compound. The following findings are drawn from this study: the main permeation barrier is located in the lipid layers; the flux and lag time of diffusion through a brick-and-mortar geometry are almost identical to the values corresponding to a multilayer geometry; the flux and lag time are affected when the lipid transbilayer diffusivity or the partition coefficients vary with depth, but are not affected by depth-dependent corneocyte diffusivity; and the follicular contribution has significance for low transbilayer lipid diffusivity, especially when flux between the follicle and the surrounding stratum corneum is involved. This study demonstrates that the diffusion is primarily transcellular and the main barrier is located in the lipid layers. Corrigendum - see https://doi.org/10.1016/j.jconrel.2017.07.033. [Description provided by NIOSH]
• Subjects:
  Drug Therapy Lipids Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Diffusion; Corneocyte; Lipid Bilayers; Skin Appendages; Partition Coefficient; Lag Time Dermal Absorption; Anisotropy; Lipids; Skin Absorption; Drug Therapy; Drugs; Diffusion Analysis;
• ISSN:
  0168-3659
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1 pdf page
• Volume:
  260
• NIOSHTIC Number:
  nn:20049993
• Citation:
  J Control Release 2017 Aug; 260:234-246
• Contact Point Address:
  Ana M. Barbero, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  abarbero@cdc.gov
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Oil and Gas Extraction
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Controlled Release
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a5a1d0d2afe91263c5d101b72402cf1ce8f71e148746ca965f7dee62ea19425feea4d9db165fff21575babad38f7119d45f05e3789034ce2a2810af2c942ab5
• Download URL:
  https://stacks.cdc.gov/view/cdc/231550/cdc_231550_DS1.pdf
• File Type:
  [PDF - 77.78 KB ]