Correction: Bladder Cancer Incidence Among Workers Exposed to O-Toluidine, Aniline and Nitrobenzene at a Rubber Chemical Manufacturing Plant

Details

• Personal Author:
  Carreon-Valencia, Tania ; Hanley, Kevin W. ; Hein, Misty J. ; Ruder, Avima M. ; Viet, S. M.
• Description:
  BACKGROUND: An earlier investigation found increased bladder cancer incidence among workers at a rubber chemical manufacturing plant that used o-toluidine, aniline and nitrobenzene. The cohort was expanded to include additional workers (n=1875) and updated through 2007 to assess bladder cancer with improved exposure characterisation. METHODS: Work histories were updated and exposure categories and ranks were developed for o-toluidine, aniline and nitrobenzene combined. Incident cancers were identified by linkage to six state cancer registries. Residency in time-dependent cancer registry catchment areas was determined. SIR and standardised rate ratios for bladder cancer were calculated by exposure category and cumulative rank quartiles for different lag periods. Cox regression was used to model bladder cancer incidence with estimated cumulative rank, adjusting for confounders. Indirect methods were used to control for smoking. RESULTS: Excess bladder cancer was observed compared to the New York State population (SIR=2.87, 95% CI 2.02 to 3.96), with higher elevations among workers definitely exposed (moderate/high) (SIR=3.90, 95% CI 2.57 to 5.68), and in the highest cumulative rank quartile (SIR=6.13, 95% CI 2.80 to 11.6, 10-year lag). Bladder cancer rates increased significantly with estimated cumulative rank (10-year lag). Smoking only accounted for an estimated 8% elevation in bladder cancer incidence. CONCLUSIONS: Bladder cancer incidence remains elevated in this cohort and significantly associated with estimated cumulative exposure. Results are consistent with earlier findings in this and other cohorts. Despite other concurrent chemical exposures, we consider o-toluidine most likely responsible for the bladder cancer incidence elevation and recommend a re-examination of occupational exposure limits. Erratum https://doi.org/10.1136/oemed-2013-101873corr1: The authors have noted an error in table 2. The upper limit of the CI should be 113.0 for row (Table Presented). [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Health Rubber Safety Urogenital System
• Keywords:
  Bladder cancer; Bladder disease; Cancer; Rubber workers; Rubber processing equipment; Rubber manufacturing industry
• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1 pdf page
• Volume:
  71
• NIOSHTIC Number:
  nn:20043581
• Citation:
  Occup Environ Med 2014 Mar; 71(3):175-182
• Contact Point Address:
  Dr. Tania Carreón, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Mailstop R-15, Cincinnati, OH 45226
• Email:
  tjc5@cdc.gov
• CAS Registry Number:
  Aniline (CAS RN 62-53-3) ; Nitrobenzene (CAS RN 98-95-3) ; o-Tolidine (CAS RN 119-93-7)
• Federal Fiscal Year:
  2014
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:72515bb6c8d9213f05dcb034108dabea62db84f5bfc640834cf5138d9a3c7fb237b402e235ea51355697127d43f8ced55190106dcea7c274876257db9b28230d
• Download URL:
  https://stacks.cdc.gov/view/cdc/231535/cdc_231535_DS1.pdf
• File Type:
  [PDF - 99.94 KB ]