Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline

Details

• Personal Author:
  Carpenter A ; Halperin, William E. ; Markowitz S ; Roberts D ; Ward E
• Description:
  A retrospective cohort study of the incidence of bladder cancer among workers exposed to o-toluidine (95534) and aniline (62533) at a chemical facility in western New York State was conducted. The company was opened in 1946 for the production of polyvinyl-chloride. Production of an antioxidant for use in tire manufacturing started in 1957. A new rubber accelerator began production in 1970. The study population was divided into three groups: workers ever employed in the department where o-toluidine and aniline were used and therefore assumed to be definitely exposed; workers in maintenance, janitorial or yard work and shipping who were possibly exposed; and all other workers not likely to have been exposed. Among all 1749 workers at the site, 13 cases of bladder cancer were observed versus 3.61 expected. Among the 708 members of group-1, seven cases were observed versus 1.08 expected. Among the 288 members of group-2, four cases were observed versus 1.09 expected. Among the remaining 753 workers, two bladder cancers were noted versus 1.43 expected. Increased risk of bladder cancer was strongly associated with increased duration of employment in the department where o-toluidine and aniline were used. [Description provided by NIOSH]
• Subjects:
  Epidemiology Manufacturing And Industrial Facilities Neoplasms Occupational Health Risk Assessment Risk Factors Rubber Safety Urogenital System
• Keywords:
  Cancer-rates Chemical-industry-workers Chemical-manufacturing-industry NIOSH-Author Risk-analysis Risk-factors Rubber-manufacturing-industry Urogenital-system
• ISSN:
  0027-8874
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  83
• Issue:
  7
• NIOSHTIC Number:
  nn:00200216
• Citation:
  J Natl Cancer Inst 1991 Apr; 83(7):501-506
• CAS Registry Number:
  Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the National Cancer Institute
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ff71e6663bf8214b8fe89026638fdcfb823d3b93da7233e01781a4d2ff4ae9307091dd58cc9d97d18ecf17b8a303e5257aa01fa02d8cda01e7115f8d450f2d6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/204718/cdc_204718_DS1.pdf
• File Type:
  [PDF - 1.54 MB ]