Parental Occupational Exposure to Solvents and Autism Spectrum Disorder: An Exploratory Look at Gene-Environment Interactions

Details

• Personal Author:
  Gu JK ; Hertz-Picciotto I ; Kashon M ; Kim K ; Ludeña-Rodriguez YJ ; Ma CC ; McCanlies EC ; Sanderson, Wayne T. ; Yucesoy, Berran
• Description:
  Highlights: Few studies have evaluated gene-environment interaction in the risk of autism spectrum disorder (ASD). Single nucleotide polymorphism (SNPs) in immune, inflammatory, antioxidant metabolism, hormone, extracellular matrix and serotonin genes were analyzed. Two experienced industrial hygienists estimated parental occupational exposure to solvents. Potential additive and multiplicative gene-environment interactions between SNPs and parental occupational exposure to solvents were evaluated. The joint presence of certain gene SNPs and parental occupational exposure to solvents is associated with higher rates of ASD above the risk associated with having the gene SNP alone or solvent exposure alone. [Description provided by NIOSH]
• Subjects:
  Environment Occupational Exposure Occupational Health Safety Solvents
• Keywords:
  ASDs Autism Spectrum Disorders Children Environmental Factors Gene Mutation Genetic Factors Occupational Exposure
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; Kentucky ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  228
• NIOSHTIC Number:
  nn:20067316
• Citation:
  Environ Res 2023 Jul; 228:115769
• Contact Point Address:
  Erin C. McCanlies, National Institute for Occupational Safety and Health, MS: L4050, 1095 Willowdale Rd. Morgantown, WV, 26505, USA
• Email:
  Eim4@cdc.gov
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Kentucky
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Environmental Research
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3aaaef7f079dccf295975844412badff7d0729bbbbfc817cc1534710c5ac3b6fcc070c96967feede72f2b0778c0ea5a208acad820a6392d8720171a6215bf140
• Download URL:
  https://stacks.cdc.gov/view/cdc/231404/cdc_231404_DS1.pdf
• File Type:
  [PDF - 655.83 KB ]