Coefficient of Friction Between Carboxymethylated Hyaluronic Acid-Based Polymer Films and the Ocular Surface

Details

• Personal Author:
  Coats B ; Colter J ; Wirostko B
• Description:
  Purpose: Hyaluronic acid-based polymer films are emerging as drug-delivery vehicles for local and continuous drug administration to the eye. The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye, reducing drug exposure and efficacy. Previous studies have shown that careful control of the surface interaction of the film with the eye is critical for improved retention. Methods: In this study, the frictional interaction of a carboxymethylated, hyaluronic acid-based polymer (CMHA-S) with and without methylcellulose was quantified against ovine and human sclera at three axial loads (0.3, 0.5, and 0.7 N) and four sliding velocities (0.3, 1.0, 10, and 30 mm/s). Results: Static coefficients of friction significantly increased with rate (P < 0.003), ranging between 0.18 +/- 0.08 and 0.46 +/- 0.13 for 0.3 to 30 mm/s, respectively. Friction became more rate-dependent when methylcellulose was added to CMHA-S. Kinetic coefficient of friction was not affected by rate, and averaged 0.15 +/- 0.1. Methylcellulose increased CMHA-S static and kinetic friction by 60% and 80%, respectively, but was also prone to wear during testing. Conclusions: These data suggest that methylcellulose can be used to create a friction differential on the film, but a potentially increased degradation rate with the methylcellulose must be considered in the design. [Description provided by NIOSH]
• Subjects:
  Drug Therapy Eye Occupational Health Safety Sense Organs Sense Organs / Injuries
• Keywords:
  Author Keywords: Ophthalmology Biomedical Engineering Biotribology Drug Delivery Drug Therapy Eye Injuries Hydrogel Medicinal Chemicals Ophthalmology Tribo-rheometry
• ISSN:
  0146-0404
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  14
• NIOSHTIC Number:
  nn:20067286
• Citation:
  Investig Ophthalmol Vis Sci 2017 Dec; 58(14):6166-6174
• Contact Point Address:
  Brittany Coats, Department of Mechanical Engineering, University of Utah, 1495 E 100 S, 1550 MEK, Salt Lake City, UT 84112, USA
• Email:
  brittany.coats@utah.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Investigative Ophthalmology & Visual Science
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c4c38ce6d9bd0cae8f31e92436d82fbcfc62ba1ba3c3385ee5190d7dba36ad353a6b28c08ce04f4c840eb663ad48ef1348586af377d70a25dc01eac814e49e88
• Download URL:
  https://stacks.cdc.gov/view/cdc/231389/cdc_231389_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]