Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective

Details

• Personal Author:
  Chang M ; Cosert KM ; Gates BL ; Jalilian I ; Kim S ; Leonard BC ; Pinkerton KE ; Raghunathan VK ; Thomasy SM ; Van Winkle LS
• Description:
  The ocular surface, comprised of the transparent cornea, conjunctiva, and protective tear film, forms a protective barrier defending deeper structures of the eye from particulate matter and mechanical trauma. This barrier is routinely exposed to a multitude of naturally occurring and engineered nanomaterials (ENM). Metallic ENMs are particularly ubiquitous in commercial products with a high risk of ocular exposure, such as cosmetics and sunscreens. Additionally, there are several therapeutic uses for metallic ENMs owing to their attractive magnetic, antimicrobial, and functionalization properties. The increasing commercial and therapeutic applications of metallic ENMs come with a high risk of ocular exposure with poorly understood consequences to the health of the eye. While the toxicity of metallic ENMs exposure has been rigorously studied in other tissues and organs, further studies are necessary to understand the potential for adverse effects and inform product usage for individuals whose ocular health may be compromised by injury, disease, or surgical intervention. This review provides an update of current literature on the ocular toxicity of metallic ENMs in vitro and in vivo, as well as the risks and benefits of therapeutic applications of metallic ENMs in ophthalmology. [Description provided by NIOSH]
• Subjects:
  Eye Metals Occupational Exposure Occupational Health Particulate Matter Safety Sense Organs Sense Organs / Injuries
• Keywords:
  Author Keywords: Metallic Engineered Nanomaterials Corneal Wound Healing Eye Eye Damage Eyes Metallic Nanoparticles Nanomaterials Nanoparticles Occupational Exposure Ocular Toxicity Ophthalmology Particulates

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• ISSN:
  1999-4923
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:20067204
• Citation:
  Pharmaceutics 2022 May; 14(5):981
• Contact Point Address:
  Sara M. Thomasy, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
• Email:
  smthomasy@ucdavis.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pharmaceutics
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ce1d6ab45d5c224ebb86a758fe6a84423b0d79fb68f909c72f4cb63483ba218e30e9af20c343f72e4707a0653976264981c7c6db53adb513d62e760046bed712
• Download URL:
  https://stacks.cdc.gov/view/cdc/231337/cdc_231337_DS1.pdf
• File Type:
  [PDF - 2.77 MB ]