Exposure to the Immunomodulatory Chemical Triclosan Differentially Impacts Immune Cell Populations in the Skin of Haired (BALB/C) and Hairless (SKH1) Mice (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Workers across every occupational sector have the potential to be exposed to a wide variety of chemicals, and the skin is a primary route of exposure. Furthermore, exposure to certain chemicals has been linked to inflammatory and allergic diseases. Thus, understanding the immune responses to chemical exposures on the skin and the potential for inflammation and sensitization is needed to improve worker safety and health. Responses in the skin microenvironment impact the potential for sensitization and these responses may include the presence of proinflammatory cytokines, inflammasome activation, barrier integrity, skin microbiota, and the presence of immune cells. Selection of mouse strain to evaluate skin effects, such as haired (BALB/c) or hairless (SKH1) mice, varies dependent on the experimental design and needs of a study. However, dermal chemical exposure may impact reactions in the skin differently depending on the strain of mouse. Additionally, there is a need for established methods to evaluate immune responses in the skin. In this study, exposure to the immunomodulatory chemical triclosan was evaluated in two mouse models using immunophenotyping by flow cytometry and gene expression analysis. The flow cytometry panel reported in this manuscript in combination with gene expression analysis may be used in future studies to better evaluate the effect of chemical exposures on the skin immune response. These findings may be important to consider during strain selection, experimental design, and result interpretation of chemical exposures on the skin. [Description provided by NIOSH]
• Subjects:
  Animals Hypersensitivity Immune System Occupational Health Safety Skin
• Keywords:
  Allergies Animal Studies Chemicals Cytokines Dermal Exposures Immune Reaction Sensitization Skin Exposure
• DOI:
  https://doi.org/10.26616/NIOSHRD-1060-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20067183
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1060-2023-0, 2023 Mar; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Phone: 304.285.6024
• CAS Registry Number:
  Triclosan (CAS RN 3380-34-5)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Exposure to the immunomodulatory chemical triclosan differentially impacts immune cell populations in the skin of haired (BALB/c) and hairless (SKH1) mice
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4681b343751e08a5b864af46ef18f404bb56b645c01fcd3c7b7f309d11fd871e8b79fa2846820b7382e77ae8c54e04a9b451d0ca46f7ff8f0bece6baceab2832
• Download URL:
  https://stacks.cdc.gov/view/cdc/231322/cdc_231322_DS1.pdf
• File Type:
  [PDF - 114.25 KB ]