Joint Association Between Ambient Air Pollutant Mixture and Pediatric Asthma Exacerbations

Details

• Personal Author:
  Bell JE ; Ford LB ; Gonzalez S ; Gwon Y ; Poole JA ; Puvvula J ; Rogan EG ; Rorie AC
• Description:
  Background: Exposure to air pollutants is known to exacerbate asthma, with prior studies focused on associations between single pollutant exposure and asthma exacerbations. As air pollutants often exist as a complex mixture, there is a gap in understanding the association between complex air pollutant mixtures and asthma exacerbations. We evaluated the association between the air pollutant mixture (52 pollutants) and pediatric asthma exacerbations. Method: This study focused on children (age ≤ 19 years) who lived in Douglas County, Nebraska, during 2016-2019. A seasonal-scale joint association between the outdoor air pollutant mixture adjusting for potential confounders (temperature, precipitation, wind speed, and wind direction) in relation to pediatric asthma exacerbation-related emergency department (ED) visits was evaluated using the generalized weighted quantile sum (qWQS) regression with repeated holdout validation. Results: We observed associations between air pollutant mixture and pediatric asthma exacerbations during spring (lagged by 5 days), summer (lag 0-5 days), and fall (lag 1-3 days) seasons. The estimate of the joint outdoor air pollutant mixture effect was higher during the summer season (adjusted-ßWQS = 1.11, 95% confidence interval [CI]: 0.66, 1.55), followed by spring (adjusted-ßWQS = 0.40, 95% CI: 0.16, 0.62) and fall (adjusted-ßWQS = 0.20, 95% CI: 0.06, 0.33) seasons. Among the air pollutants, PM2.5, pollen, and mold contributed higher weight to the air pollutant mixture. Conclusion: There were associations between outdoor air pollutant mixture and pediatric asthma exacerbations during the spring, summer, and fall seasons. Among the 52 outdoor air pollutant metrics investigated, PM2.5, pollen (sycamore, grass, cedar), and mold (Helminthosporium, Peronospora, and Erysiphe) contributed the highest weight to the air pollutant mixture. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Asthma Asthma, Occupational Epidemiology Fungi Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollutants Air Pollution Author Keywords: Ambient Air Pollutants Children Mixed Exposures Mixture Molds Particulates Pediatric Asthma Exacerbations Seasonal Factors
• ISSN:
  2474-7882
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  5
• NIOSHTIC Number:
  nn:20067156
• Citation:
  Environ Epidemiol 2022 Oct; 6(5):e225
• Contact Point Address:
  Jesse E. Bell, Department Environmental Agricultural and Occupational Health, University of Nebraska Medical Center, 987810 Nebraska Medical Center, Omaha, NE 68198
• Email:
  Jesse.bell@unmc.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Environmental Epidemiology
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5873b46038df24f42d927e6acdf6698ead4b62859c0250db8f42f9565c4ab682a96c45c972826899c763980162c74e4f7dad5af18e73c561169cf14fd0e14e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/231304/cdc_231304_DS1.pdf
• File Type:
  [PDF - 780.59 KB ]