In-Home Particle Concentrations and Childhood Asthma Morbidity

Details

• Personal Author:
  Breysse PN ; Curtin-Brosnan J ; Diette GB ; Eggleston P ; Hansel NN ; Matsui EC ; McCormack MC ; Williams D
• Corporate Authors:
  Center for Childhood Asthma in the Urban Environment
• Description:
  Background: Although outdoor particulate matter (PM) has been linked to mortality and asthma morbidity, the impact of indoor PM on asthma has not been well established. Objective: This study was designed to investigate the effect of in-home PM on asthma morbidity. Methods: For a cohort of 150 asthmatic children (2-6 years of age) from Baltimore, Maryland, a technician deployed environmental monitoring equipment in the children's bedrooms for 3-day intervals at baseline and at 3 and 6 months. Caregivers completed questionnaires and daily diaries during air sampling. Longitudinal data analyses included regression models with generalized estimating equations. Results: Children were primarily African Americans (91%) from lower socioeconomic backgrounds and spent most of their time in the home. Mean (+/- SD) indoor PM(2.5-10) (PM with aerodynamic diameter 2.5-10 microm) and PM(2.5) (aerodynamic diameter < 2.5 microm) concentrations were 17.4 +/- 21.0 and 40.3 +/- 35.4 microg/m(3). In adjusted models, 10-microg/m(3) increases in indoor PM(2.5-10) and PM(2.5) were associated with increased incidences of asthma symptoms: 6% [95% confidence interval (CI), 1 to 12%] and 3% (95% CI, -1 to 7%), respectively; symptoms causing children to slow down: 8% (95% CI, 2 to 14%) and 4% (95% CI, 0 to 9%), respectively; nocturnal symptoms: 8% (95% CI, 1 to 14%) and 6% (95% CI, 1 to 10%), respectively; wheezing that limited speech: 11% (95% CI, 3 to 19%) and 7% (95% CI, 0 to 14%), respectively; and use of rescue medication: 6% (95% CI, 1 to 10%) and 4% (95% CI, 1 to 8%), respectively. Increases of 10 microg/m(3) in indoor and ambient PM(2.5) were associated with 7% (95% CI, 2 to 11%) and 26% (95% CI, 1 to 52%) increases in exercise-related symptoms, respectively. Conclusions: Among preschool asthmatic children in Baltimore, increases in in-home PM(2.5-10) and PM(2.5) were associated with respiratory symptoms and rescue medication use. Increases in in-home and ambient PM(2.5) were associated with exercise-related symptoms. Although reducing PM outdoors may decrease asthma morbidity, reducing PM indoors, especially in homes of inner-city children, may lead to improved asthma health. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Asthma Asthma, Occupational Morbidity Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airborne Particulates Air Pollution Author Keywords: Air Pollution Children IAQ Indoor Indoor Air Quality Morbidity Rates Particulate Matter Particulates Pediatric Respiratory Irritants Respiratory System Disorders Urban

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  294-298
• Volume:
  117
• Issue:
  2
• NIOSHTIC Number:
  nn:20062773
• Citation:
  Environ Health Perspect 2009 Feb; 117(2):294-298
• Contact Point Address:
  G.B. Diette, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument St., 5th Floor, Baltimore, MD 21205 USA
• Email:
  gdiette@jhmi.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7f5d42b0dbc14eb506ba1556429d149c35ccd17824ccc579b99bce240ef89a9c10cb408fec41ceab0ae538234ad5554f9a728f679978e01fa1755f6d7eee59d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/225963/cdc_225963_DS1.pdf
• File Type:
  [PDF - 180.36 KB ]