Heart Failure and Late-Onset Alzheimer’s Disease: A Mendelian Randomization Study

Details

• Personal Author:
  Arega Y ; Shao Y
• Description:
  Some observational studies suggested that heart failure (HF) is associated with increased risk of late-onset Alzheimer's disease (AD). On the other hand, a recently published Two-Sample Mendelian Randomization (2SMR) study was reported as inconclusive but the estimated odds ratios (ORs) were less than one indicating a potential causal association between genetically predicted HF and lowered risk of AD. Both HF and AD are quite common among elderly persons and frequently occur together resulting in a series of severe medical challenges and increased financial burden on healthcare. It is of great medical and financial interest to further investigate the statistical significance of the potential causal associations between genetically predicted HF and lowered risk of AD using large independent cohorts. To fill this important knowledge gap, the present study used the 2SMR method based on summary data from a recently published large genome-wide association study (GWAS) for AD on subjects with European ancestry. The 2SMR analysis provided statistically significant evidence of an association with ORs less than one between genetically predicted HF and late onset AD (Inverse Variance Weighted, OR = 0.752, p = 0.004; MR Egger, OR = 0.546, p = 0.100; Weighted Median, OR = 0.757, p = 0.014). Further investigations of the significant associations between HF and late-onset AD, including specific genes related to the potential protective effect of HF-related medications on cognitive decline, are warranted. [Description provided by NIOSH]
• Subjects:
  Aging Cardiovascular Diseases Cardiovascular System Delivery Of Health Care Mental Disorders Mental Health Occupational Health Safety
• Keywords:
  Age Groups Author Keywords: Alzheimer's Disease Causal Association Genetic Factors Genetic Predisposition GWAS Health Care Heart Disease Heart Failure Medical Care Mendelian Randomization Mental Disorders SNPs Vascular Dementia

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• ISSN:
  1664-8021
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• NIOSHTIC Number:
  nn:20066952
• Citation:
  Front Genet 2022 Nov; 13:1015674
• Contact Point Address:
  Yongzhao Shao, Department of Population Health, New York University Grossman School of Medicine, New York, NY
• Email:
  Yongzhao.Shao@nyulangone.org
• Federal Fiscal Year:
  2023
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20220701
• Source Full Name:
  Frontiers in Genetics
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16f504e24dfc3f170c87b3119c9856ccced213d78bb9854c51658ddfba0e91386ad0c13f7d40db7872f3dd1a6d13eb59078f7c3a74acbbd5eff0646cf13f31ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/231224/cdc_231224_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]