Cholesteryl Ester Transfer Protein Genotype Modifies the Effect of Apolipoprotein e4 on Memory Decline in Older Adults

Details

• Personal Author:
  Derby CA ; Hall CB ; Katz M ; Lipton RB ; Ozelius LJ ; Sunderman EE ; Wang C ; Zimmerrman ME
• Description:
  Apolipoprotein e4 (ApoE4) is a strong genetic risk factor for sporadic Alzheimer's disease and memory decline in older adults. A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer's disease. As both genes regulate cholesterol, we hypothesized that the favorable CETPV405 allele may buffer the effect of ApoE4 on memory decline in older adults. Using linear regression, we examined the interactive effect of ApoE4 by CETPV405 on memory decline among 909 community-dwelling, nondemented, older adults (=70 years) from the Einstein Aging Study. Episodic memory was measured using the picture version of the Free and Cued Selective Reminding Test with immediate recall (pFCSRT+IR). There was a significant ApoE × CETP interaction on decline in pFCSRT+IR scores (p = 0.01). ApoE4 carriers experienced faster decline than noncarriers among CETPI405I homozygotes (p = 0.007) and in CETPI405V heterozygotes (p = 0.015) but not in CETPV405V homozygotes (p = 0.614). Results suggest that the CETPV405 allele buffers ApoE4-associated memory decline in a gene dose-dependent manner. [Description provided by NIOSH]
• Subjects:
  Aging Genetics Men Mental Disorders Mental Health Occupational Health Risk Assessment Risk Factors Safety Women
• Keywords:
  Age Groups Author Keywords: ApoE E4 CETP Gene-gene Interaction Genes Genetic Factors Humans I405V Memory Decline Mental Disorders Proteins Risk Factors

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• ISSN:
  0197-4580
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• NIOSHTIC Number:
  nn:20053857
• Citation:
  Neurobiol Aging 2016 May; 41:200.e7-200.e12
• Contact Point Address:
  Erin Elizabeth Sundermann, Department of Neurology, Albert Einstein College of Medicine, 1225 Morris Park Avenue, Van Etten 3C5B, Bronx, NY 10461
• Email:
  erin.sundermann@einstein.yu.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Neurobiology of Aging
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a247b0c1cc490a6b4b8ff34d2486eddc05376db41db5482960f29a406c0772a91b5fa0db735d9e364957bb3421d06ee146c3001fe583617fabfac199fdbeb73a
• Download URL:
  https://stacks.cdc.gov/view/cdc/216545/cdc_216545_DS1.pdf
• File Type:
  [PDF - 382.54 KB ]