Biological Effects of Inhaled Crude Oil Vapor VI. Altered Biogenic Amine Neurotransmitters and Neural Protein Expression (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In the oil and gas industry, workers are potentially exposed to crude oil or crude oil vapor (COV) during upstream (drilling and extraction), midstream (transportation and storage), as well as downstream (refining) activities. Worker exposure to various fractions of crude oil have been linked to mortality, as well as musculoskeletal, respiratory, gastrointestinal, circulatory problems, and cancer. During the Gulf of Mexico Deepwater Horizon (DWH) oil spill, response workers were exposed to a variety of chemical hazards including volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), heavy metals, as well as components of the oil dispersants employed to disperse the oil. The Gulf Long-term Follow-up (GuLF) STUDY had reported that workers involved in the cleanup operations experienced adverse hematologic, pulmonary, hepatic, and cardiac problems. However, long-term neurological effects remain unknown. Health Hazard Evaluation (HHE) surveys conducted by NIOSH among the cleanup workers identified a variety of health effects, including neurological symptoms. Unfortunately, as a significant number of response workers who experienced health symptoms were exposed to both crude oil and the oil dispersant that was aerially sprayed to the contain the spill, the health effects of crude oil exposures alone were difficult to discern from these surveys. It is here that laboratory-based studies are advantageous as they can provide ample health risk information to establish the toxicological potential of the various chemical hazards at the workplace. To that end, the present work evaluated the neurotoxic risks of COV generated from the Macondo well crude oil that was used as a surrogate for the DWH crude oil. [Description provided by NIOSH]
• Subjects:
  Animals Nervous System Occupational Health Oil And Gas Industry Respiratory System Safety Volatile Organic Compounds
• Keywords:
  Animal Studies Crude Oil Gas Industry Health Effects Inhalation Neurological System Neurotoxic Effects Neurotransmitters Oil Industry Oil Vapors VOCs Volatile Organic Compounds

  More +
• DOI:
  https://doi.org/10.26616/NIOSHRD-1051-2022-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20066615
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1051-2022-0, 2023 Jan; :dataset
• Contact Point Address:
  Toxicology and Molecular Biology Branch (TMBB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505. Phone: 304-285-6272
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b2bb917eb3e256656c848e84e879fc87e28a6fb7660349ae96bbf0edeb1f2cb0cef2d6eb4067814c94b683cd0817fdcdaa99bfb6ed33e7a0cf7f448ad4cc46f
• Download URL:
  https://stacks.cdc.gov/view/cdc/231136/cdc_231136_DS1.pdf
• File Type:
  [PDF - 157.73 KB ]