Biological Effects of Inhaled Crude Oil Vapor V. Altered Biogenic Amine Neurotransmitters and Neural Protein Expression

Details

• Journal Article:
  Toxicology and Applied Pharmacology
• Personal Author:
  Sriram, Krishnan ; Lin, Gary X. ; Jefferson, Amy M. ; McKinney, Walter G. ; Jackson, Mark C. ; Cumpston, Jared L. ; Cumpston, James B. ; Leonard, Howard D. ; Kashon, Michael L. ; Fedan, Jeffrey S.
• Description:
  Workers in the oil and gas industry are at risk for exposure to a number of physical and chemical hazards at the workplace. Chemical hazard risks include inhalation of crude oil or its volatile components. While several studies have investigated the neurotoxic effects of volatile hydrocarbons, in general, there is a paucity of studies assessing the neurotoxicity of crude oil vapor (COV). Consequent to the 2010 Deepwater Horizon (DWH) oil spill, there is growing concern about the short- and long-term health effects of exposure to COV. NIOSH surveys suggested that the DWH oil spill cleanup workers experienced neurological symptoms, including depression and mood disorders, but the health effects apart from oil dispersants were difficult to discern. To investigate the potential neurological risks of COV, male Sprague-Dawley rats were exposed by whole-body inhalation to COV (300 ppm; Macondo surrogate crude oil) following an acute (6 h/d × 1 d) or sub-chronic (6 h/d × 4 d/wk. × 4 wks) exposure regimen. At 1, 28 or 90 d post-exposure, norepinephrine (NE), epinephrine (EPI), dopamine (DA) and serotonin (5-HT) were evaluated as neurotransmitter imbalances are associated with psychosocial-, motor- and cognitive- disorders. Sub-chronic COV exposure caused significant reductions in NE, EPI and DA in the dopaminergic brain regions, striatum (STR) and midbrain (MB), and a large increase in 5-HT in the STR. Further, sub-chronic exposure to COV caused upregulation of synaptic and Parkinson's disease-related proteins in the STR and MB. Whether such effects will lead to neurodegenerative outcomes remain to be investigated. [Description provided by NIOSH]
• Subjects:
  Air Pollution Animals Gases Inhalation Exposure Nervous System Nervous System Diseases Neurotransmitter Agents Occupational Health Oil And Gas Industry Petroleum Rats Respiratory System Safety Serotonin Toxicology Volatile Organic Compounds Water Pollutants

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• Keywords:
  Author Keywords: Brain; Inhalants; Inhalation Studies; Neurological Disorders; Neurotoxicity; Neurotoxicology; Occupational Exposure Limits; Oil And Gas; Parkinsonism; Psychosocial; Toxicology; Volatile Organic Compounds Oil Vapors; Oil Industry; Gas Industry; Crude Oil; Inhalation; Health Effects; Animal Studies; Volatile Organic Compounds; VOCs; Neurological System; Neurotoxic Effects; Neurotransmitters;
• Source:
  Toxicol Appl Pharmacol 2022 Aug; 449:116137
• ISSN:
  0041-008X
• Pubmed ID:
  35750205
• Pubmed Central ID:
  PMC9936428
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  32 pdf pages
• Volume:
  449
• NIOSHTIC Number:
  nn:20065551
• Contact Point Address:
  Krishnan Sriram, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1000 Frederick Drive, Mailstop L-3014, Morgantown, WV 26508, United States of America
• Email:
  kos4@cdc.gov
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Oil and Gas Extraction
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:bb7b08dfc19544e33189995287547041d9eadc80fe8463781147dea13839d38c27093fd7d782978cdbb31f490adbfac5ef29c0e0e08bf6ccf23a909f71b17a4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/124825/cdc_124825_DS1.pdf
• File Type:
  [PDF - 4.15 MB ]