Temporal Aspects of the Association Between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma

Details

• Personal Author:
  Boffetta P ; Brackbill RM ; Cone, James E. ; Dasaro CR ; Farfel MR ; Goldfarb DG ; Hall CB ; Kahn AR ; Kristjansson D ; Li J ; Prezant DJ ; Qiao B ; Schymura MJ ; Todd AC ; Webber MP ; Yung J ; Zeig-Owens R
• Description:
  Rescue/recovery workers who responded to the World Trade Center (WTC) attacks were exposed to known/suspected carcinogens. Studies have identified a trend toward an elevated risk of cutaneous melanoma in this population; however, few found significant increases. Furthermore, temporal aspects of the association have not been investigated. A total of 44,540 non-Hispanic White workers from the WTC Combined Rescue/Recovery Cohort were studied between March 12, 2002 and December 31, 2015. Cancer data were obtained through linkages with 13 state registries. Poisson regression was used to estimate hazard ratios and 95% confidence intervals using the New York State population as the reference; change points in hazard ratios were estimated using profile likelihood. We observed 247 incident cases of melanoma. No increase in incidence was detected during 2002-2004. From 2005 to 2015, the hazard ratio was 1.34 (95% confidence interval = 1.18-1.52). A dose-response relationship was observed by arrival time at the WTC site. Risk was elevated just over 3 years after the attacks. Whereas WTC-related exposures to UVR or other agents might have contributed to this result, exposures other than those at the WTC site, enhanced medical surveillance, and lack of a control group with a similar proportion of rescue/recovery workers cannot be discounted. Our results support continued study of this population for melanoma. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Emergency Responders Epidemiology Neoplasms Occupational Health Safety September 11 Terrorist Attacks Skin Skin Diseases
• Keywords:
  Cancer Rates Cohort Studies Disaster Recovery Longitudinal Study Medical Screening Rescue Workers Skin Cancer World Trade Center WTC
• ISSN:
  2667-0267
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• Issue:
  1
• NIOSHTIC Number:
  nn:20066583
• Citation:
  JID Innov 2022 Jan; 2(1):100063
• Contact Point Address:
  Paolo Boffetta, Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, New York 11794, USA
• Email:
  paolo.boffetta@stonybrookmedicine.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Albert Einstein College of Medicine, Inc., Bronx, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  JID Innovations
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e15d932cb5e77cdef495f53b376a9b98eaaff4fcb95424b3e9bac019fe184d50dfda04dd5978035fd4a92b2c987384f92ae8bccde626bb768069217787448bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/231132/cdc_231132_DS1.pdf
• File Type:
  [PDF - 378.67 KB ]