Systemic Toxicity Induced by Topical Application of Perfluoroheptanoic Acid (PFHpA), Perfluorohexanoic Acid (PFHxA), and Perfluoropentanoic Acid (PFPeA) in a Murine Model

Details

• Personal Author:
  Anderson, Stacey E. ; Baur R ; Lukomska E ; Shane HL ; Weatherly LM
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic structurally diverse chemicals incorporated into industrial and consumer products. PFHpA, PFHxA, and PFPeA are carboxylic PFAS (C7, C6, C5, respectively) labeled as a safer alternative to legacy carboxylic PFAS due to their shorter half-life in animals. Although there is a high potential for dermal exposure, these studies are lacking. The present study conducted analyses of serum chemistries, immune phenotyping, gene expression, and histology to evaluate the systemic toxicity of a sub-chronic 28-day dermal exposure of alternative PFAS (1.25-5% or 31.25-125 mg/kg/dose) in a murine model. Liver weight (% body) significantly increased with PFHpA, PFHxA, and PFPeA exposure and histopathological changes were observed in both the liver and skin. Gene expression changes were observed with PPAR isoforms in the liver and skin along with changes in genes involved in steatosis, fatty acid metabolism, necrosis, and inflammation. These findings, along with significant detection levels in serum and urine, support PFAS-induced liver damage and PPARa, d, and gamma involvement in alternative PFAS systemic toxicity and immunological disruption. This demonstrates that these compounds can be absorbed through the skin and brings into question whether these PFAS are a suitable alternative to legacy PFAS. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Immune System Occupational Exposure Occupational Health Safety Skin Toxicology
• Keywords:
  Animal Studies Author Keywords: Perfluoroheptanoic Acid Dermal Dermal Exposures Gene Expression Immune Immune Reaction Liver Damage Occupational Exposure Per- And Polyfluoroalkyl Substances Perfluorohexanoic Acid Perfluoropentanoic Acid PFAS PFHpA PFHxA PFPeA Ppar Toxic Effects Toxicity

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• ISSN:
  0278-6915
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  171
• NIOSHTIC Number:
  nn:20066455
• Citation:
  Food Chem Toxicol 2023 Jan; 171:113515
• Contact Point Address:
  Lisa M. Weatherly, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505, USA
• Email:
  nux6@cdc.gov
• CAS Registry Number:
  Perfluoroheptanoic acid (CAS RN 375-85-9) ; Perfluorohexanoic acid (CAS RN 307-24-4) ; Perfluoropentanoic acid (CAS RN 2706-90-3)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing ; Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Food and Chemical Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:814d62f4844d6135d37c26e52e6fd897e947161ae0fcdd075bb1a9ad28eacf8b2720564e8d4fbc9c17004616a44f86611965cb0af0fccd9273ba6370966e9d50
• Download URL:
  https://stacks.cdc.gov/view/cdc/231091/cdc_231091_DS1.pdf
• File Type:
  [PDF - 4.82 MB ]