CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Details

• Personal Author:
  Genov R ; Li H ; Li L ; Liu X ; Mason AJ ; Mu X
• Description:
  Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Amperometry Author Keywords: Electrochemical Biological Monitoring Biosensor Biosensors Current Readout Electrochemical Analysis Electronic Circuits Emerging Technology Impedance Spectroscopy Potentiostat Wearable Technologies

  More +
• ISSN:
  1424-8220
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; Missouri ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  74
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:20067484
• Citation:
  Sensors 2017 Jan; 17(1):74
• Contact Point Address:
  Haitao Li, Maxim Integrated Products Inc., 160 Rio Robles, San Jose, CA 95134, USA
• Email:
  haitaoli7036@gmail.com
• Federal Fiscal Year:
  2017
• Performing Organization:
  Michigan State University
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Sensors
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:487b779ca61d4ce69bd3cc3f8c65ce66948398a440b72d33b043a89bd447804c8af6eaea66da1a910ba0c682575964a5b9a6d23ae8aa61d8853763d5f135b7ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/231033/cdc_231033_DS1.pdf
• File Type:
  [PDF - 6.85 MB ]