A Highly Sensitive and Long-Term Stable Wearable Patch for Continuous Analysis of Biomarkers in Sweat

Details

• Personal Author:
  Abdullah AM ; Barai S ; Biswas MAS ; Cheng H ; Das S ; Dutta A ; Li B ; Liu Y ; Lorestani F ; Niu Z ; Rahman MM ; Wang K ; Xin X ; Zhang X
• Description:
  Although increasing efforts have been devoted to the development of non-invasive wearable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by facile laser treatment for detecting biomarkers such as glucose in sweat. The laser-reduced and patterned stable conductive nanocomposite on the porous graphene electrode provides the resulting glucose sensor with an excellent sensitivity of 1317.69 µA mm-1 cm-2 and an ultra-low limit of detection of 0.079 µm. The sensor can also detect pH and exhibit extraordinary stability to maintain more than 91% sensitivity over 21 days in ambient conditions. Taken together with a temperature sensor based on the same material system, the dual glucose and pH sensor integrated with a flexible microfluidic sweat sampling network further results in accurate continuous on-body glucose detection calibrated by the simultaneously measured pH and temperature. The low-cost, highly sensitive, and long-term stable platform could facilitate the early identification and continuous monitoring of different biomarkers for non-invasive disease diagnosis and treatment evaluation. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Author Keywords: Accurate Glucose Sensing Biomedical Engineering Electrochemical Analysis Emerging Technology Flexible Electrochemical Biosensors Laser Treatment Long-term Stability Materials Testing Nanocomposites Porous Graphene Nanocomposite Electrode Sensors Wearable Technologies

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• ISSN:
  1616-301X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  12
• NIOSHTIC Number:
  nn:20069467
• Citation:
  Adv Funct Mater 2023 Dec; 33(12):2306117
• Contact Point Address:
  Farnaz Lorestani, Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802 USA
• Email:
  fkl5072@psu.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Pennsylvania State University
• Peer Reviewed:
  True
• Start Date:
  20220901
• Source Full Name:
  Advanced Functional Materials
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:02dbde58b4230cd516654e34922abc9b976780f271f15601eea4e91c8e96043e94d899cb52ec7e6c45d6ecba4fada031353a9aab900d20d868c8c948f2798867
• Download URL:
  https://stacks.cdc.gov/view/cdc/207904/cdc_207904_DS1.pdf
• File Type:
  [PDF - 3.63 MB ]