Preliminary Investigation of a Hypertonic Saline Nasal Rinse as a Hygienic Intervention in Dairy Workers

Details

• Personal Author:
  Bradford, Mary ; Erlandson, Grant ; Jones, Kenneth ; Magzamen, Sheryl ; Mitra, Sanchayita ; Nonnenmann, Matthew ; Poole, Jill A. ; Reynolds, Stephen J. ; Schaeffer, Joshua W. ; Sharp, Julia L.
• Description:
  Livestock workers experience an increased burden of bioaerosol-induced respiratory disease including a high prevalence of rhinosinusitis. Dairy operations generate bioaerosols spanning the inhalable size fraction (0-100 µm) containing bacterial constituents such as endotoxin. Particles with an aerodynamic diameter between 10 and 100 µm are known to deposit in the nasopharyngeal region and likely affect the upper respiratory tract. We evaluated the effectiveness of a hypertonic saline nasal lavage in reducing inflammatory responses in dairy workers from a high-volume dairy operation. Inhalable personal breathing zone samples and pre-/post-shift nasal lavage samples from each participant over five consecutive days were collected. The treatment group (n = 5) received hypertonic saline while the control group (n = 5) received normotonic saline. Personal breathing zone samples were analyzed for particulate concentrations and endotoxin using gravimetric and enzymatic methods, respectively. Pro- and anti-inflammatory cytokines (i.e., IL-8, IL-10, and TNF-a) were measured from nasal lavage samples using a multiplex assay. Inhalable dust concentrations ranged from 0.15 to 1.9 mg/m3. Concentrations of both pro- and anti-inflammatory cytokines, specifically IL-6, IL-8, and IL-10, were significantly higher in the treatment group compared to the control group (p < 0.02, p < 0.04, and p < 0.01, respectively). Further analysis of IL-10 anti-inflammatory indicates a positive association between hypertonic saline administration and IL-10 production. This pilot study demonstrates that hypertonic saline nasal lavages were successful in upregulating anti-inflammatory cytokines to support larger interventional studies. [Description provided by NIOSH]
• Subjects:
  Agriculture Dairy Products Livestock Nose Occupational Health Safety Sense Organs
• Keywords:
  Agricultural Workers Author Keywords: Agricultural Health Bioaerosols Cytokines Dairy Products Inflammation Intervention Effectiveness Livestock Industry Nasal Cavity Nasal Lavage
• ISSN:
  1545-9624
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Iowa ; Nebraska ; OSHA Region 7 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10 pdf pages
• Volume:
  20
• Issue:
  1
• NIOSHTIC Number:
  nn:20067152
• Citation:
  J Occup Environ Hyg 2023 Jan; 20(1):14-22
• Contact Point Address:
  Joshua W. Schaeffer, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
• Email:
  josh.schaeffer@colostate.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Colorado State University, Fort Collins, Colorado
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73fd687d1b8aba37061d531d35b7b082527d90be6ebae2c434861111d5d7615710f138bff389d9f9ed36a5922f9dea06efd3d73dbe4b4a863157f148dd45cd4c
• Download URL:
  https://stacks.cdc.gov/view/cdc/230846/cdc_230846_DS1.pdf
• File Type:
  [PDF - 1.46 MB ]