Mixture Analysis on Associations Between Semen Quality and Sperm DNA Integrity and Occupational Exposure to Polycyclic Aromatic Hydrocarbons

Details

• Personal Author:
  Chang-Chien, Guo-Ping ; Chao, Mu-Rong ; Jeng, Hueiwang A. ; Lin, Wen-Yi ; Pan, Chih-Hong ; Sikdar, Sinjini
• Description:
  The objective of this study was to assess relationships between exposure to PAHs at occupational levels and outcomes of human semen quality and sperm DNA integrity. Personal breathing zone air samples were collected to quantify exposure of 16 targeted PAHs to coke-oven workers at a steel company in southern Taiwan. Semen quality, including concentration, motility, morphology, and viability, were assessed. Sperm DNA fragmentation, 8-oxodGuo, bulky PAH adducts, and benzo[a]pyrene diol epoxide-DNA adducts served as biomarkers for assessment of sperm DNA integrity. The Bayesian Kernel Machine Regression modeling was employed to estimate mixture effects of the PAH mixture on the outcomes of semen quality and sperm DNA integrity and to identify individual compounds of PAH mixtures associated with the mixture effects. Exposure to the PAH mixture was inversely associated with sperm viability, while benzo(b)fluoranthene (B[b]F) was identified as the main predictor for sperm viability. Exposure to the PAH mixture also exhibited a positive trend with sperm DNA fragmentation. B[b]F and benzo(a)anthracene (B[a]A) were identified as individual PAH compounds associated with increased sperm DNA fragmentation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Hydrocarbons Men Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety Urogenital System
• Keywords:
  Author Keywords: Bay Regions Benzo(b)fluoranthene DNA Damage Mixture Analysis Occupational Exposure Polycyclic Aromatic Hydrocarbons Reproductive Effects Spermatozoa
• ISSN:
  1933-8244
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15 pdf pages
• Volume:
  78
• Issue:
  1
• NIOSHTIC Number:
  nn:20067251
• Citation:
  Arch Environ Occup Health 2023 Jan; 78(1):14-27
• Contact Point Address:
  Hueiwang Anna Jeng, School of Community and Environmental Health, Old Dominion University, 4608 Hampton Blvd., Health Sciences Building Room 3122, Norfolk, VA 23509
• Email:
  hjeng@odu.edu
• CAS Registry Number:
  Benz[e]acephenanthrylene (CAS RN 205-99-2)
• Federal Fiscal Year:
  2023
• Performing Organization:
  Old Dominion University, Norfolk, Virginia
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Archives of Environmental & Occupational Health
• End Date:
  20120831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:28a7f7cf7e5b2e2e6306742c7fa0ee77c88a8a88923a136b2d942462407cab284e50802da724f9dc82af3e4cb30d68141a55926bbb848ce35742d406f96ca4d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/230845/cdc_230845_DS1.pdf
• File Type:
  [PDF - 2.54 MB ]