Exposure to Metalworking Fluids and Cancer Incidence in the United Auto Workers-General Motors Cohort

Details

• Personal Author:
  Chen, Kevin T. ; Colbeth, Hilary L. ; Costello, Sadie ; Eisen, Ellen A. ; Picciotto, Sally
• Description:
  In previous studies, investigators have reported increased risks of specific cancers associated with exposure to metalworking fluids (MWFs). In this report we broadly examine the incidence of 14 types of cancer, with a focus on digestive, respiratory, and hormonal cancers, in the United Auto Workers-General Motors (UAW-GM) cohort, a cohort of workers exposed to MWFs (1973-2015). The cohort included 39,132 workers followed for cancer incidence. Cox models yielded estimates of adjusted hazard ratios, with categorical variables for lagged cumulative exposure to 3 types of MWF (straight, soluble, and synthetic). We fitted penalized splines to examine the shape of the exposure-response relationships. There were 7,809 incident cancer cases of interest. Oil-based straight and soluble MWFs were each modestly associated with all cancers combined. Exposure-response patterns were consistent with prior reports from this cohort, and results for splined exposures generally reflected their categorically modeled counterparts. We found significantly increased incidence of stomach and kidney cancer with higher levels of straight MWF exposure and increased rectal and prostate cancer with increasing water-based synthetic MWF exposure. Only non-Hodgkin lymphoma and prostate cancer were associated with soluble MWF. All results for colon and lung cancers were null. Our results provide updated evidence for associations between MWF exposure and incidence of several types of cancer. [Description provided by NIOSH]
• Subjects:
  Automobiles Cohort Studies Epidemiology Labor Unions Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Cohort Studies Automotive Industry Cancer Rates Cohort Studies Incidence Metal Workers Metalworking Metalworking Fluids MWFs Occupational Exposure Occupational Health Proportional Hazards Models

  More +
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11 pdf pages
• Volume:
  192
• Issue:
  2
• NIOSHTIC Number:
  nn:20067135
• Citation:
  Am J Epidemiol 2023 Feb; 192(2):171-181
• Contact Point Address:
  Hilary L. Colbeth, Division of Epidemiology, School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720-7360
• Email:
  hcolbeth@berkeley.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20180915
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20210914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:03d0b78fe8ba0588f210f2027a3a1368fd459a4bb1fef1c2561d1a63599718e399f69de04e4b71ae070d1783aa91fcbb04fa53d3e685e3621d465924ebaf90d0
• Download URL:
  https://stacks.cdc.gov/view/cdc/230831/cdc_230831_DS1.pdf
• File Type:
  [PDF - 570.56 KB ]