Nasal Nitric Oxide Flux from the Paranasal Sinuses

Details

• Personal Author:
  Shusterman, Dennis J. ; Spector, Barak M. ; Zhao, Kai
• Description:
  Purpose of review: Upper airway nitric oxide (NO) is physiologically important in airway regulation and defense, and can be modulated by various airway inflammatory conditions, including allergic rhinitis and chronic rhinosinusitis - with and without polyposis. Paranasal sinuses serve as a NO 'reservoir', with concentrations typically exceeding those measured in lower airway (fractional exhaled NO or FeNO) by a few orders of magnitude. However, the dynamics of NO flux between the paranasal sinuses and main nasal airway, which are critical to respiratory NO emission, are poorly understood. Recent findings: Historically, NO emissions were thought to be contributed mostly by the maxillary sinuses (the largest sinuses) and active air movement (convection). However, recent anatomically-accurate computational modeling studies based on patients' CT scans showed that the ethmoid sinuses and diffusive transport dominate the process. Summary: These new findings may have a substantial impact on our view of nasal NO emission mechanisms and sinus physiopathology in general. [Description provided by NIOSH]
• Subjects:
  Anatomy Hypersensitivity Immune System Nitric Oxide Nose Occupational Health Safety Sense Organs
• Keywords:
  Allergies Immune Reaction Nasal Cavity Nitric Oxide Physiopathology Respiratory Gases
• ISSN:
  1528-4050
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  23
• Issue:
  1
• NIOSHTIC Number:
  nn:20067121
• Citation:
  Curr Opin Allergy Clin Immunol 2023 Feb; 23(1):22-28
• Contact Point Address:
  Kai Zhao, PhD, Department of Otolaryngology - Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212, USA
• Email:
  Zhao.1949@osu.edu
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Current Opinion in Allergy and Clinical Immunology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d192404e5aacfacf5d03d2b46da11ab4df51c37be7aabd3ad6b18cee57ad7d338f8e7c35cc78fba8c275d68509e5759c483d0254c854c1cf2cc0c5781d2cccbd
• Download URL:
  https://stacks.cdc.gov/view/cdc/230802/cdc_230802_DS1.pdf
• File Type:
  [PDF - 1.32 MB ]