Vibration Disrupts Vascular Function in a Model of Metabolic Syndrome

Details

• Personal Author:
  Johnson C ; Kiedrowski M ; Krajnak, Kristine M. ; Miller R ; Waugh, Stacey ; Johnson C ; Kiedrowski M ; Krajnak, Kristine M. ; Miller R ; Waugh, Stacey
• Description:
  Vibration-induced white finger (VWF) is a disorder seen in workers exposed to hand-transmitted vibration, and is characterized by cold-induced vasospasms and ringer blanching. Because overweight people with metabolic syndrome are pre-disposed to developing peripheral vascular disorders, it has been suggested that they also may be at greater risk of developing VWF if exposed to occupational vibration. We used an animal model of metabolic syndrome, the obese Zucker rat, to determine if metabolic syndrome alters vascular responses to vibration. Tails of lean and obese Zucker rats were exposed to vibration (125 Hz, 49 m/s(2) r.m.s.) or control conditions for 4 h/d for 10 d. Ventral tail arteries were collected and assessed for changes in gene expression, levels of reactive oxygen species (ROS) and for responsiveness to vasomodulating factors. Vibration exposure generally reduced the sensitivity of arteries to acetylcholine (ACh)-induced vasodilation. This decrease in sensitivity was most apparent in obese rats. Vibration also induced reductions in vascular nitric oxide concentrations and increases in vascular concentrations of ROS in obese rats. These results indicate that vibration interferes with endothelial-mediated vasodilation, and that metabolic syndrome exacerbates these effects. These findings are consistent with idea that workers with metabolic syndrome have an increased risk of developing VWF. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Laboratories Nitric Oxide Occupational Health Safety Sense Organs Vibration
• Keywords:
  Author Keywords: Vibration-induced White Finger Endothelial Function Laboratory-animals Nitric Oxide Obesity Reactive Oxygen Species Sensitization Sensory-motor-system Vasomotor-system Vasomotor-system-disorders Vibration-effects Vibration-exposure Zucker Rats

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• ISSN:
  0019-8366
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  47
• Issue:
  5
• NIOSHTIC Number:
  nn:20036012
• Citation:
  Ind Health 2009 Sep; 47(5):533-542
• Contact Point Address:
  Kristine Krajnak, Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
• Email:
  kkrajnak@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3fab60e01f795c1bf75e6d437a21c709576208f2d767c71257c825e49f652f8a6149c5c571ba77dce53f9f06388682069dc8982fa8e272965e774ef0f22270d
• Download URL:
  https://stacks.cdc.gov/view/cdc/187637/cdc_187637_DS1.pdf
• File Type:
  [PDF - 130.19 KB ]