Radon and Lung Cancer in the Pooled Uranium Miners Analysis (PUMA): Highly Exposed Early Miners and All Miners

Details

• Personal Author:
  Bertke, Stephen J. ; Deffner, Veronika ; Demers, Paul A. ; Fenske, Nora ; Kelly-Reif, Kaitlin ; Kreuzer, Michaela ; Laurier, Dominique ; Rage, Estelle ; Richardson, David B. ; Samet, Jonathan ; Schubauer-Berigan, Mary K. ; Tomasek, Ladislav ; Wiggins, Charles ; Zablotska, Lydia B.
• Description:
  Objectives: Radon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners. Methods: The pooled uranium miners analysis combines 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained between 1946 and 2014. The association between cumulative radon exposure in working level months (WLM) and lung cancer was modelled as the excess relative rate (ERR) per 100 WLM using Poisson regression; variation in the association by temporal and exposure factors was examined. We also examined analyses restricted to miners first hired before 1960 and with <100 WLM cumulative exposure. Results: In a model that allows for variation by attained age, time since exposure and annual exposure rate, the ERR/100 WLM was 4.68 (95% CI 2.88 to 6.96) among miners who were less than 55 years of age and were exposed in the prior 5 to <15 years at annual exposure rates of <0.5 WL. This association decreased with older attained age, longer time since exposure and higher annual exposure rate. In analyses restricted to men first hired before 1960, we observed similar patterns of association but a slightly lower estimate of the ERR/100 WLM. Conclusions: This new large, pooled study confirms and supports a linear exposure-response relationship between cumulative radon exposure and lung cancer mortality which is jointly modified by temporal and exposure factors. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Lung Lung Diseases Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Uranium
• Keywords:
  Cancer Rates Cohort Studies Lung Cancer Mortality Rates Radiation Exposure Radon Uranium Miners
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; New Mexico ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  80
• NIOSHTIC Number:
  nn:20067567
• Citation:
  Occup Environ Med 2023 Jul; 80(7):385-391
• Contact Point Address:
  Dr Kaitlin Kelly-Reif, Division of Field Studies and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
• Email:
  kkelly-reif@cdc.gov
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3cd9cfcb4adedddc33355d9980910a39ad19de106c1ba43b5aa08efb92ae32a2f3987ae45bd1c2a1e72ceab1122d77b56ab64e3dae6847bd4700969234a65e2b
• Download URL:
  https://stacks.cdc.gov/view/cdc/230691/cdc_230691_DS1.pdf
• File Type:
  [PDF - 542.06 KB ]