PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Wang, Wei; Song, Zhigang; Guan, Wencai; Liu, Yi; Zhang, Xiaonan; Xu, Lei; Li, Jianhua; Yuan, Zhenghong; Hu, Yunwen

doi:10.3201/eid2005.131364

i

PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Supporting Files Public Domain

May 2014
By Wang, Wei ; Song, Zhigang ; Guan, Wencai ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Wang, Wei ; Song, Zhigang ; Guan, Wencai ; Liu, Yi ; Zhang, Xiaonan ; Xu, Lei ; Li, Jianhua ; Yuan, Zhenghong ; Hu, Yunwen
Description:

Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR and single nucleotide polymorphism probes to differentiate this mutant strain in mixed virus populations in human specimens.
Subjects:

Dispatch H7N9 Influenza Influenza A(H7N9) Virus Influenza Virus Mutation NA 292K Mutant Virus Neuraminidase Oseltamivir Resistance R292K Wild-type Virus Real-time Reverse Transcription PCR Real-time RT-PCR Single-nucleotide Polymorphism SNP Viruses
Source:

Emerg Infect Dis. 20(5):847-849.
Document Type:

Journal Article
Volume:

20
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2c26ddc8f6a15cfda29c68cbbf6f711adb67c63782e4e791a834c350dc8076e8
Download URL:

https://stacks.cdc.gov/view/cdc/23064/cdc_23064_DS1.pdf
File Type:

[PDF - 321.28 KB ]

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