Cancer Patients

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Shelburne, Samuel A. ; Sahasrabhojane, Pranoti. ; Saldana, Miguel. ; Yao, Hui. ; Su, Xiaoping. ; Horstmann, Nicola. ; Thompson, Erika. ; Flores, Anthony R.
• Description:
  The genetically diverse viridans group streptococci (VGS) are increasingly recognized as the cause of a variety of human diseases. We used a recently developed multilocus sequence analysis scheme to define the species of 118 unique VGS strains causing bacteremia in patients with cancer; Streptococcus mitis (68 patients) and S. oralis (22 patients) were the most frequently identified strains. Compared with patients infected with non-S. mitis strains, patients infected with S. mitis strains were more likely to have moderate or severe clinical disease (e.g., VGS shock syndrome). Combined with the sequence data, whole-genome analyses showed that S. mitis strains may more precisely be considered as >2 species. Furthermore, we found that multiple S. mitis strains induced disease in neutropenic mice in a dose-dependent fashion. Our data define the prominent clinical effect of the group of organisms currently classified as S. mitis and lay the groundwork for increased understanding of this understudied pathogen.
• Subjects:
  Bacteremia Bacteria Cancer Cancer Patients Characterization Multilocus Sequence Analysis Neutropenia Pitt Bacteremia Score Research Streptococcus Mitis Viridans Group Streptococci

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• Source:
  Emerg Infect Dis. 20(5):762-771.
• Document Type:
  Journal Article
• Volume:
  20
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:986d45e7161db4e53cb5cb1074e0b12710b7e8c0ee2696d087fd5b8eee8dbc6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/23056/cdc_23056_DS1.pdf
• File Type:
  [PDF - 961.83 KB ]