Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Shelburne, Samuel A. ; Sahasrabhojane, Pranoti. ; Saldana, Miguel. ; Yao, Hui. ; Su, Xiaoping. ; ... More +
Shelburne, Samuel A. ; Sahasrabhojane, Pranoti. ; Saldana, Miguel. ; Yao, Hui. ; Su, Xiaoping. ; Horstmann, Nicola. ; Thompson, Erika. ; Flores, Anthony R. Less -
Description:
The genetically diverse viridans group streptococci (VGS) are increasingly recognized as the cause of a variety of human diseases. We used a recently developed multilocus sequence analysis scheme to define the species of 118 unique VGS strains causing bacteremia in patients with cancer; Streptococcus mitis (68 patients) and S. oralis (22 patients) were the most frequently identified strains. Compared with patients infected with non-S. mitis strains, patients infected with S. mitis strains were more likely to have moderate or severe clinical disease (e.g., VGS shock syndrome). Combined with the sequence data, whole-genome analyses showed that S. mitis strains may more precisely be considered as >2 species. Furthermore, we found that multiple S. mitis strains induced disease in neutropenic mice in a dose-dependent fashion. Our data define the prominent clinical effect of the group of organisms currently classified as S. mitis and lay the groundwork for increased understanding of this understudied pathogen.
Subjects:
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Bacteremia Bacteria Cancer Cancer Patients Characterization Multilocus Sequence Analysis Neutropenia Pitt Bacteremia Score Research Streptococcus Mitis Viridans Group Streptococci
Source:
Emerg Infect Dis. 20(5):762-771.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:986d45e7161db4e53cb5cb1074e0b12710b7e8c0ee2696d087fd5b8eee8dbc6b
Download URL:
https://stacks.cdc.gov/view/cdc/23056/cdc_23056_DS1.pdf
File Type:

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