Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan

Sada, Ryuichi Minoda; Matsuo, Hiroo; Motooka, Daisuke; Kutsuna, Satoshi; Hamaguchi, Shigeto; Yamamoto, Go; Ueda, Akiko

doi:10.3201/eid3004.231633

i

Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan

Supporting Files Public Domain

4 2024
By Sada, Ryuichi Minoda ; Matsuo, Hiroo ; Motooka, Daisuke ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Sada, Ryuichi Minoda ; Matsuo, Hiroo ; Motooka, Daisuke ; Kutsuna, Satoshi ; Hamaguchi, Shigeto ; Yamamoto, Go ; Ueda, Akiko
Description:

Clostridium butyricum, a probiotic commonly prescribed in Asia, most notably as MIYA-BM (Miyarisan Pharmaceutical Co., Ltd.; https://www.miyarisan.com), occasionally leads to bacteremia. The prevalence and characteristics of C. butyricum bacteremia and its bacteriologic and genetic underpinnings remain unknown. We retrospectively investigated patients admitted to Osaka University Hospital during September 2011-February 2023. Whole-genome sequencing revealed 5 (0.08%) cases of C. butyricum bacteremia among 6,576 case-patients who had blood cultures positive for any bacteria. Four patients consumed MIYA-BM, and 1 patient consumed a different C. butyricum-containing probiotic. Most patients had compromised immune systems, and common symptoms included fever and abdominal distress. One patient died of nonocclusive mesenteric ischemia. Sequencing results confirmed that all identified C. butyricum bacteremia strains were probiotic derivatives. Our findings underscore the risk for bacteremia resulting from probiotic use, especially in hospitalized patients, necessitating judicious prescription practices.
Subjects:

Bacteremia Clostridium Butyricum Humans Probiotics Retrospective Studies
Keywords:

Bacteremia Bacteria Burkholderia Pseudomallei History Inappropriate Prescribing Japan Melioidosis Probiotics
Source:

Emerg Infect Dis. 2024; 30(4):665-671
Pubmed ID:

38413242
Pubmed Central ID:

PMC10977840
Document Type:

Journal Article
Place as Subject:

Japan
Volume:

30
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b37ff8dddf07980a6b886c211418e3b3752793dae9fbbb5bfd42ff0b2a599ca9
Download URL:

https://stacks.cdc.gov/view/cdc/152973/cdc_152973_DS1.pdf
File Type:

[PDF - 517.54 KB ]

File Language:

English

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