Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Sáfadi, Marco Aurelio Palazzi ; Carvalhanas, Telma Regina Marques Pinto ; Paula de Lemos, Ana ; Gorla, Maria Cecilia Outeiro ; Salgado, Maristela ; ... More +
Sáfadi, Marco Aurelio Palazzi ; Carvalhanas, Telma Regina Marques Pinto ; Paula de Lemos, Ana ; Gorla, Maria Cecilia Outeiro ; Salgado, Maristela ; Fukasawa, Lucila O. ; Gonçalves, Maria Gisele ; Higa, Fabio ; Brandileone, Maria Cristina Cunto ; Sacchi, Claudio Tavares ; Ribeiro, Ana Freitas ; Sato, Helena Keico ; Bricks, Lucia Ferro ; Cassio de Moraes, José Less -
Description:
During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries in São Paulo State, Brazil, leading to mass vaccination of employees at 1 refinery with a meningococcal polysaccharide A/C vaccine. A cross-sectional study was conducted to assess the prevalence of meningococci carriage among workers at both refineries and to investigate the effect of vaccination on and the risk factors for pharyngeal carriage of meningococci. Among the vaccinated and nonvaccinated workers, rates of overall meningococci carriage (21.4% and 21.6%, respectively) and of MenC carriage (6.3% and 4.9%, respectively) were similar. However, a MenC strain belonging to the sequence type103 complex predominated and was responsible for the increased incidence of meningococcal disease in Brazil. A low education level was associated with higher risk of meningococci carriage. Polysaccharide vaccination did not affect carriage or interrupt transmission of the epidemic strain. These findings will help inform future vaccination strategies.
Subject:
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Adolescent
Adult
Carrier State
Cross-Sectional Studies
Disease Outbreaks
History, 21st Century
Humans
Incidence
Meningitis, Meningococcal/classification
Meningitis, Meningococcal/genetics
Meningitis, Meningococcal/immunology
Meningococcal Infections/epidemiology
Meningococcal Infections/history
Meningococcal Infections/prevention & Control
Meningococcal Vaccines
Multilocus Sequence Typing
Research
Risk Factors
Serotyping
Vaccination
Young Adult

Source:
Emerg Infect Dis. 20(5):806-811.
Document Type:
Journal Article
Place as Subject:
Brazil
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:00488c936f40ec16390986d716b8cb023a49f9971c4ebd15f56d8983696f3a3b
File Type:

Supporting Files

• 	13-0948.nxml	txt
  	license.txt	txt

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