Prostate Cancer Risk and Outcome in WTC Respondents

Details

• Personal Author:
  Taioli E
• Description:
  An excess incidence of prostate cancer has been identified among World Trade Center (WTC) rescue and recovery workers included in the WTC Health Program (WTCHP) at Mount Sinai in New York. An excess has also been reported among WTC-exposed firefighters included in a separate program. It is unclear whether the excess is associated with WTC-related exposures or represents an artifact. Although no environmental agents are established prostate carcinogens, the understanding of the etiology and pathogenesis of prostate cancer - the most common cancer in US men - is limited, and the investigation of high-risk populations might offer new clues. Conversely, the finding that excess risk among WTCHP participants is not attributable to WTC related exposures, but to other factors (for example over-diagnosis because of enhanced surveillance) would represent an important reassuring message to WTCHP members. The objectives of this project are to elucidate the reasons for the increased incidence of prostate cancer among WTCHP participants and to explore the behavior of these cancers. An analysis of cancer risk according to WTC-related exposures was already planned. This project complemented that analysis by looking at other reasons for an increased prostate cancer risk and investigating whether prostate cancers among WTCHP participants differ from a clinical, epidemiologic and molecular viewpoint from prostate cancers in WTC-unrelated patients diagnosed at Mount Sinai. [Description provided by NIOSH]
• Subjects:
  Emergency Responders Epidemiology Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cancer Rates Emergency Responders Pathogenesis Prostate Cancer Rescue Workers World Trade Center WTC
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-10
• NIOSHTIC Number:
  nn:20055667
• NTIS Accession Number:
  PB2019-100846
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-010396, 2017 Sep; :1-10
• Contact Point Address:
  Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1075, New York, New York 10029
• Federal Fiscal Year:
  2017
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20130701
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ea6ed093876d124277e5bafa85f4f33b8eca8cea6995404bb4f2d21cc2c222aea6779f27a6ca543b6bc0b5f860361eec5328e93318b83731e01e065b24cf439a
• Download URL:
  https://stacks.cdc.gov/view/cdc/218860/cdc_218860_DS1.pdf
• File Type:
  [PDF - 275.77 KB ]