Chronic Parenchymal Lung Disease Radiological Abnormalities and Declining Longitudinal FEV1 Trajectory in WTC Workers and Volunteers

Details

• Personal Author:
  Antoniak K ; de la Hoz RE ; Doucette JT ; Jeon Y ; Liu X ; Weber J
• Description:
  Background: Occupational health exposures at the WTC site after September 11, 2001 have been associated with several inflammatory lower airway diseases among WTC workers and volunteers. In this study, we examined whether expiratory airflow slope trajectories are correlated with semiquantitative visual radiological scores for interstitial lung disease abnormalities (rounded opacities, linear opacities, ground glass opacities, and honeycombing), and emphysema. Methods: We selected the first-second forced expiratory volume (FEV1 ) to establish the expiratory air flow trajectories of 1348 former WTC workers and volunteers with at least 3 periodic spirometries, and available semiquantitative CT scan scores ("sumgrades") according to the International Classification for Occupational and Environmental Disease (ICOERD). We calculated individual FEV1 slope regression lines, and then classified subjects as "stable", "gainers" or "decliners" based on their FEV1slope. We then used multivariable logistic regression to model decliner vs. stable trajectories in a dichotomous model that compared those with higher and lower scores for each of the selected radiological abnormalities. Results: We observed a statistically significant unadjusted association between decliner FEV1slope, and groundglass opacity (p=0.024), but multivariable analysis failed to show significance. Conclusions: Groundglass opacities were the only of the 5 examined radiological abnormalities associated with declining FEV1slope in this study in unadjusted, but not adjusted analyses. Studies with larger sample sizes and longer follow-up time merit further research. [Description provided by NIOSH]
• Subjects:
  Lung Occupational Health Radiation Respiratory Function Tests Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Imaging Techniques Longitudinal Study Lung Function Radiology Spirometry World Trade Center WTC
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  199
• NIOSHTIC Number:
  nn:20068340
• Citation:
  Am J Respir Crit Care Med 2019 May; 199(Abstract Issue):A1862
• Email:
  rafael.delahoz@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20120901
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstract Issue
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:47d42c9279760eb8ba94af59f87ef2b8b96751918dcabb281a72067cef82258723427029a6ba0bbd164e49611a0b195df5320052f2a98ed1e90ab91b0fa1e6f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/230506/cdc_230506_DS1.pdf
• File Type:
  [PDF - 117.02 KB ]