Low Serum IgA and Airway Injury in World Trade Center-Exposed Firefighters: A 17-Year Longitudinal Study

Details

• Personal Author:
  Goldfarb D ; Hall CB ; Lahousse L ; Liu Y ; Prezant DJ ; Putman B ; Schwartz T ; Singh A ; Webber MP ; Weiden MD ; Zeig-Owens R
• Description:
  Serum IgA ≤ 70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤ 70 mg/dL was associated with worse lung function and increased antibiotic treatment. [Description provided by NIOSH]
• Subjects:
  Dust Firefighters Lung Occupational Health Respiratory Function Tests Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Chronic Obstructive Pulmonary Disease COPD Dust Exposure Fire Fighters Longitudinal Study Lung Function Spirometry World Trade Center WTC
• ISSN:
  0040-6376
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• Issue:
  12
• NIOSHTIC Number:
  nn:20057753
• Citation:
  Thorax 2019 Dec; 74(12):1182-1184
• Contact Point Address:
  Dr. Michael D. Weiden, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
• Email:
  Michael.Weiden@nyumc.org
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Thorax
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3cb704d6a707cfbde1dcdbc0fdfefab3b283627b62d39b2a42b0ced5406ca3d37980756489235c7ed77f4797294d16cfd52811f181bf2dd41a0ba27083ce9267
• Download URL:
  https://stacks.cdc.gov/view/cdc/214990/cdc_214990_DS1.pdf
• File Type:
  [PDF - 290.52 KB ]