Toxicant Effects on Mammalian Oocyte Mitochondria

Details

• Personal Author:
  Luderer U ; Malott KF
• Description:
  Oocyte mitochondria are unique organelles that establish a founder population in primordial germ cells (PGCs). As the oocyte matures in the postnatal mammalian ovary during folliculogenesis it increases exponentially in volume, and the oocyte mitochondria population proliferates to about 100 000 mitochondria per healthy, mature murine oocyte. The health of the mature oocyte and subsequent embryo is highly dependent on the oocyte mitochondria. Mitochondria are especially sensitive to toxic insults, as they are a major source of reactive oxygen species (ROS), they contain their own DNA (mtDNA) that is unprotected by histone proteins, they contain the electron transport chain that uses electron donors, including oxygen, to generate ATP, and they are important sensors for overall cellular stress. Here we review the effects that toxic insults including chemotherapeutics, toxic metals, plasticizers, pesticides, polycyclic aromatic hydrocarbons (PAHs), and ionizing radiation can have on oocyte mitochondria. This is very clearly a burgeoning field, as our understanding of oocyte mitochondria and metabolism is still relatively new, and we contend much more research is needed to understand the detrimental impacts of exposure to toxicants on oocyte mitochondria. Developing this field further can benefit our understanding of assisted reproductive technologies and the developmental origins of health and disease (DOHaD). [Description provided by NIOSH]
• Subjects:
  Antioxidants Hydrocarbons Occupational Health Polycyclic Aromatic Hydrocarbons Safety Urogenital System
• Keywords:
  Author Keywords: PAHs Chemotherapy Germ Cells Ionizing Radiation Metals Mitochondria Oocyte Oxidative Stress Pesticides Plasticizers Polycyclic Aromatic Hydrocarbons Reactive Oxygen Species Reproductive Effects ROS

  More +
• ISSN:
  0006-3363
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  104
• Issue:
  4
• NIOSHTIC Number:
  nn:20068278
• Citation:
  Biol Reprod 2021 Apr; 104(4):784-793
• Contact Point Address:
  Ulrike Luderer, Center for Occupational and Environmental Health, 100 Theory Drive, Suite 100, Irvine, CA 92617, USA
• Email:
  uluderer@uci.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Biology of Reproduction
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e427ef08379a96ec55de609d036ca7ddfece6626a55f1bb758f26a9088d3b49c3ba42cbfe2e0a8db98b97d0b84b29be1d0d4be7407a3f168cbb638936cf06e7f
• Download URL:
  https://stacks.cdc.gov/view/cdc/230458/cdc_230458_DS1.pdf
• File Type:
  [PDF - 382.77 KB ]