How Did the 2022 Global Mpox Outbreak Happen? A Travel-Associated Case 6 Months Earlier May Provide Important Clues

Details

• Personal Author:
  Baird N ; Blythe D ; Chen T-H ; Crum D ; Davidson WB ; De Perio, Marie A. ; Duwell M ; Gigante CM ; Hughes CM ; Kim AM ; Kreuze MA ; Li Y ; Lowe D ; Lukula SL ; McCollum AM ; Minhaj FS ; Myers R ; Perlmutter R ; Rao AK ; Ravi-Caldwell N ; Rubin JH ; Sockwell D ; Wilkins K
• Description:
  Approximately 6 months before an unprecedented global mpox outbreak was first identified in the United Kingdom, an adult man was diagnosed with mpox in Maryland, USA. At the time of the investigation, the case was only the eighth monkeypox virus (MPXV) infection diagnosed in a non-African country during the preceding 3 years, all of which were associated with recent travel to Nigeria. One of these 8 imported cases occurred in Texas, USA four months earlier; that case exhibited features clinically consistent with those classically reported in Africa (i.e., large and diffuse lesions, high fever and prodromal symptoms, umbilicated lesions in the same stage of development on specific anatomic surfaces). In contrast, the Maryland case was milder in severity and had signs that, at the time, were considered unusual for mpox. Several aspects of the Maryland case are noteworthy and in retrospect may offer clues to the origins of the 2022 global mpox outbreak, as well as explain how mpox might have spread undetected before emerging as a global outbreak. [Description provided by NIOSH]
• Subjects:
  Air Conditioning Electricity Mining Occupational Health Safety
• Keywords:
  Author Keywords: Mpox Disease Transmission Infectious Diseases Monkeypox Mpox Orthopoxvirus Sequencing Transportation Viral Infections
• ISSN:
  1873-0442
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Georgia ; Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  55
• NIOSHTIC Number:
  nn:20068182
• Citation:
  Travel Med Infect Dis 2023 Sep-Oct; 55:102618
• Contact Point Address:
  Molly A. Kreuze, Department of Health, 201 W. Preston Street, Office 323A, Baltimore, MD, 21201
• Email:
  rhv5@cdc.gov
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  True
• Source Full Name:
  Travel Medicine and Infectious Disease
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:975f639dd2f305ca20c58496411c64e3c7e4537dbe1f2bce18a6417397d5fd690848cd70bc48727597fa7d6c5e6af65d051379ec1a380b65b13b41d03fc88294
• Download URL:
  https://stacks.cdc.gov/view/cdc/230392/cdc_230392_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]