Lung Deposition Versus Inhalable Sampling to Estimate Body Burden of Welding Fume Exposure: A Pilot Sampler Study in Stainless Steel Welders

Details

• Personal Author:
  Adams K ; Dickinson LM ; Koehler K ; Newton A ; Serdar B
• Description:
  This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed for inhalable and lung-deposited nickel and chromium and urine was analyzed for the respective biomarkers of internal dose. There were statistically significant relationships between lung-deposited nickel (βNi = 0.10; 95% CI = 0.05-0.16) and chromium (βCr = 0.07; 95% CI = 0.006-0.14) and their internal dose biomarkers. No relationship was found between inhalable metals and internal dose biomarkers. In moving towards a more physiologically relevant exposure metric, the LDS can provide better estimates for the total body burden of exposure than traditional penetration-based samplers. [Description provided by NIOSH]
• Subjects:
  Aerosols Biomarkers Lung Occupational Health Particulate Matter Respiratory System Safety Welding
• Keywords:
  Author Keywords: Sampler Validation Inhalation Studies Lung Deposition Particle Aerodynamics Particle Size Stainless Steel Welding Aerosols Welding Fumes
• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Idaho ; Maryland ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  153
• NIOSHTIC Number:
  nn:20068181
• Citation:
  J Aerosol Sci 2021 Mar; 153:105721
• Contact Point Address:
  Kirsten Koehler, Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health and Engineering, 615 N Wolfe St, Baltimore, MD, 21205, USA
• Email:
  kkoehle1@jhu.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:57f080f25f8a52af309cf9c811c22bad9dd110378a68d1cc06c02df83b6172c1bcfdc388a40281bb225aefaf11553cc612cfaa901ad865599da5748eff6748f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/230391/cdc_230391_DS1.pdf
• File Type:
  [PDF - 3.11 MB ]