Maternal Occupational Exposure to Selected Organic and Chlorinated Solvents and Delivery of Small-for-Gestational Age or Preterm Infants

Details

• Personal Author:
  Ailes EC ; Chen I-C ; Desrosiers TA ; Politis MD ; Rocheleau CM ; Sanderson, Wayne T. ; Van Buren KW
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Background: Potential reproductive effects of organic solvent exposure during pregnancy remain unclear. We investigated the association between maternal occupational exposure during pregnancy to six chlorinated solvents, three aromatic solvents, and Stoddard solvent, and delivery of preterm infants or those born small-for-gestational age (SGA). Methods: In this case-control study of SGA and preterm birth (PTB) nested within the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we analyzed data from 7504 singleton live births without major birth defects and their mothers. Self-reported information on jobs held in the periconceptional period was assessed for solvent exposure. Unconditional logistic regression was used to estimate the association between maternal occupational exposure (any, none) during early pregnancy to organic solvents and PTB and SGA. Linear regression was used to examine changes in mean birthweight potentially associated with maternal occupational solvent exposure. Results: Maternal occupational exposure to any organic solvents overall was not associated with an increased odds of PTB (adjusted odds ratio [aOR] = 0.94; 95% confidence interval [CI] 0.67-1.33) or SGA (aOR = 0.93; 95% CI 0.65-1.34). Point estimates increased modestly for higher estimated exposure versus lower, but confidence intervals were wide and not statistically significant. Maternal exposure to solvents was not associated with a statistically significant change in term birthweight among infants. Conclusions: Occupational exposure to organic solvents at the frequency and intensity levels found in a population-based sample of pregnant workers was not associated with PTB or SGA; however, we cannot rule out any effects among pregnant workers with uncommonly high exposure to organic solvents. [Description provided by NIOSH]
• Subjects:
  Hydrocarbons Occupational Health Pregnancy Safety Solvents Urogenital System Women
• Keywords:
  Author Keywords: SGA Birth Weight Chlorinated Solvents Occupation Occupations Organic Solvents Prenatal Exposure Preterm Birth Reproductive Health Stoddard Solvent Worker

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant ; Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Georgia ; Kentucky ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  66
• Issue:
  10
• NIOSHTIC Number:
  nn:20068027
• Citation:
  Am J Ind Med 2023 Oct; 66(10):842-853
• Contact Point Address:
  Kristen W. Van Buren, Division of Field Studies and Engineering, National Institute for Occupational Safety and Health, Cincinnati, OH
• Email:
  opv7@cdc.gov
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Kentucky, Lexington
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20240630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3980de55de630b003b2af6ed43cf3ca2ff3f4309fb7551e6805ae1f0ca14d7922490ac91e08462d486306a475c1c0d3aee51abbe1bb65f68a97049c48fa52430
• Download URL:
  https://stacks.cdc.gov/view/cdc/230251/cdc_230251_DS1.pdf
• File Type:
  [PDF - 883.28 KB ]