Mixture Analysis of Associations Between Exposure to Low Levels of Multiple Metals and Semen Quality and Sperm DNA Integrity

Details

• Personal Author:
  Huang Y-L ; Jeng HA ; Pan C-H ; Sikdar S
• Description:
  The objective of this study was to assess the association of exposure to metal mixtures with semen quality and sperm DNA integrity of coke oven workers (n = 96). Urinary six metals (cadmium, lead, arsenic, zinc, selenium, and copper) were quantified using inductively coupled-mass spectrometry. Semen quality parameters included sperm concentration, sperm concentration, sperm motility, sperm morphology, and sperm viability. Sperm DNA fragmentation and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) adducts served as biomarkers for assessing sperm DNA integrity. Bayesian kernel machine regression with the hierarchical variable selection process was used for analyzing both individual and joint effects of the metal mixture on the outcomes of semen samples, while adjusting for age, smoking, alcohol consumption, job length, and body mass index. The metal mixture was associated with reduced sperm concentration, motility, viability, and normal morphology. It was novel that a dose-response relationship was observed between exposure of the metal mixture and semen quality. Among the metals tested, cadmium had a reverse relationship with sperm motility, viability, and normal morphology, and a non-linear relationship with sperm viability and sperm motility. The metal mixture and individual metals were not associated with sperm DNA fragmentation and 8-oxodGuo. In conclusion, exposure to metal mixtures and cadmium may exert an association with semen quality and had no association with sperm DNA breakages. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cadmium Men Metals Occupational Exposure Occupational Health Safety Urogenital System
• Keywords:
  Author Keywords: Metals Coke Oven Workers DNA Damage Mixed Exposures Mixture Analysis Occupational Exposure Reproductive Effects Semen Quality Spermatozoa
• ISSN:
  0360-1226
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  318-326
• Volume:
  57
• Issue:
  4
• NIOSHTIC Number:
  nn:20067920
• Citation:
  J Environ Sci Health. Part A, Environ Sci Eng 2022 Apr; 57(4):318-326
• Contact Point Address:
  Hueiwang Anna Jeng, School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, USA
• Email:
  HJeng@odu.edu
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  2022
• Performing Organization:
  Old Dominion University, Norfolk, Virginia
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Journal of Environmental Science and Health. Part A: Environmental Science and Engineering
• End Date:
  20120831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ba365c52b65dca82f582b7a820b87de9f4a5fc55e37355e4127bd739227fe928d10b3274d10ac64a5c45126d9d4c08444ccdc19e1541e96bf3db14c9f023fad
• Download URL:
  https://stacks.cdc.gov/view/cdc/230154/cdc_230154_DS1.pdf
• File Type:
  [PDF - 1.84 MB ]