A Cross-Sectional Examination of the Early-Onset Hypertensive Disorders of Pregnancy and Industrial Emissions of Toxic Metals Using Kentucky Birth Records, 2008–2017

Details

• Personal Author:
  Browning SR ; Christian WJ ; Kucharska-Newton A ; Walker CJ
• Description:
  This cross-sectional study assessed geospatial patterns of early-onset hypertensive disorders of pregnancy (eHDP) in primiparous mothers and exposure to industrial emissions using geocoded residential information from Kentucky live (N = 210,804) and still (N = 1,247) birth records (2008-2017) and census block group estimates of aerosol concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zi) from the Risk Screening Environmental Indicators (RSEI) model. A latent class analysis allowed for the identification of four district exposure classes-As, Cd, and Pb (12.6%); Se and Zi (21.4%); Pb and Cr (8%); and low or no exposures (57.9%). Women classified as having a high probability of exposure to both Pb and Cr had a statistically significantly greater prevalence of eHDP after adjusting for demographic factors (aPR = 1.22, 95% CI: 1.04, 1.44) relative to those with low or no exposure. Our findings contribute to the emerging literature on the association of metal exposures with pregnancy outcomes. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Environmental Exposure Epidemiology Metals Occupational Health Pregnancy Safety
• Keywords:
  Blood Pressure Cross Sectional Studies Environmental Exposure Hypertension Industrial Emissions Prenatal Exposure
• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  9
• NIOSHTIC Number:
  nn:20067829
• Citation:
  PLoS One 2022 Sep; 17(9):e0274250
• Contact Point Address:
  Courtney J. Walker, Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, Kentucky, United States of America
• Email:
  Courtney.Walker@Uky.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Kentucky
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  PLoS One
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:decafde16981c0ea89c4f850786303d07e69cbb684204e995c23993d3f28142df4f23bc7fc7affd8d88b6eb4a8e304e0b71dcaae762939e706b493637342a125
• Download URL:
  https://stacks.cdc.gov/view/cdc/230084/cdc_230084_DS1.pdf
• File Type:
  [PDF - 1.71 MB ]