Sex Hormones and Diabetes in 45- to 74-Year-Old Men and Postmenopausal Women: The Hispanic Community Health Study

Details

• Personal Author:
  Abasilim C ; Cai J ; Chavez N ; Daviglus ML ; Day T ; Freels S ; Grieco A ; Isasi CR ; Kaplan R ; Madrigal JM ; Meyer ML ; Persky V ; Peters BA ; Pirzada A ; Sargis RM ; Talavera GA ; Thyagarajan B ; Tsintsifas K ; Turyk ME ; Unterman T
• Description:
  Previous studies demonstrated associations of endogenous sex hormones with diabetes. Less is known about their dynamic relationship with diabetes progression through different stages of the disease, independence of associations, and role of the hypothalamic-pituitary gonadal axis. The purpose of this analysis was to examine relationships of endogenous sex hormones with incident diabetes, prediabetes, and diabetes traits in 693 postmenopausal women and 1015 men aged 45 to 74 years without diabetes at baseline participating in the Hispanic Community Health Study/Study of Latinos and followed for 6 years. Baseline hormones included estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), and, in men, testosterone and bioavailable testosterone. Associations were analyzed using multivariable Poisson and linear regressions. In men, testosterone was inversely associated with conversion from prediabetes to diabetes (incidence rate ratio [IRR] for 1 SD increase in testosterone: 0.821; 95% CI, 0.676, 0.997; P = 0.046), but not conversion from normoglycemia to prediabetes. Estradiol was positively associated with increase in fasting insulin and homeostatic model assessment of insulin resistance. In women, SHBG was inversely associated with change in glycosylated hemoglobin, postload glucose, and conversion from prediabetes to diabetes (IRR = 0.62; 95% CI, 0.44, 0.86, P = 0.005) but not from normoglycemia to prediabetes. Relationships with other hormones varied across glycemic measures. Stronger associations of testosterone and SHBG with transition from prediabetes to diabetes than from normoglycemic to prediabetes suggest they are operative at later stages of diabetes development. Biologic pathways by which sex hormones affect glucose homeostasis await future studies. [Description provided by NIOSH]
• Subjects:
  Aging Blood Endocrine System Epidemiology Hematologic Diseases Occupational Health Race Factors Safety Sex Characteristics
• Keywords:
  Age Groups Author Keywords: Diabetes Blood Sugar Disorders Endocrinology Hormone Activity Hormones Racial Factors Sex Sex Factors
• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Illinois ; Minnesota ; New York ; North Carolina ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  108
• Issue:
  7
• NIOSHTIC Number:
  nn:20067810
• Citation:
  J Clin Endocrinol Metab 2023 Jul; 108(7):1709-1726
• Contact Point Address:
  Victoria Persky, M.D., Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, 1603 Taylor St., Chicago, IL 60612
• Email:
  vwpersky@uic.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:26128353c06f875ca9231560626f9d1e9094c2e8a5b144622f36c5e303a44d227e3d726d3b872c38495fe01737e00f10dbbcacf842efe487cde333565ae3b9a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/230066/cdc_230066_DS1.pdf
• File Type:
  [PDF - 703.53 KB ]