Impact of White Matter Hyperintensities on Subjective Cognitive Decline Phenotype in a Diverse Cohort of Cognitively Normal Older Adults

Details

• Personal Author:
  Bernard MA ; Briggs AQ ; Favilla C ; Masurkar AV ; Rothstein A ; Shao Y ; Sloane K ; Witsch J ; Zhang Y
• Description:
  Objectives; Subjective cognitive decline (SCD) is a preclinical stage of AD. White matter hyperintensities (WMH), an MRI marker of cerebral small vessel disease, associate with AD biomarkers and progression. The impact of WMH on SCD phenotype is unclear. Methods/Design: A retrospective, cross-sectional analysis was conducted on a diverse cohort with SCD evaluated at the NYU Alzheimer's Disease Research Center between January 2017 and November 2021 (n = 234). The cohort was dichotomized into none-to-mild (n = 202) and moderate-to-severe (n = 32) WMH. Differences in SCD and neurocognitive assessments were evaluated via Wilcoxon or Fisher exact tests, with p-values adjusted for demographics using multivariable logistic regression. Results: Moderate-to-severe WMH participants reported more difficulty with decision making on the Cognitive Change Index (1.5 SD 0.7 vs. 1.2 SD 0.5, p = 0.0187) and worse short-term memory (2.2 SD 0.4 vs. 1.9 SD 0.3, p = 0.0049) and higher SCD burden (9.5 SD 1.6 vs. 8.7 SD 1.7, p = 0.0411) on the Brief Cognitive Rating Scale. Moderate-to-severe WMH participants scored lower on the Mini-Mental State Examination (28.0 SD 1.6 vs. 28.5 SD 1.9, p = 0.0491), and on delayed paragraph (7.2 SD 2.0 vs. 8.8 SD 2.9, p = 0.0222) and designs recall (4.5 SD 2.3 vs. 6.1 SD 2.5, p = 0.0373) of the Guild Memory Test. Conclusions: In SCD, WMH impact overall symptom severity, specifically in executive and memory domains, as well as objective performance on global and domain-specific tests in verbal memory and visual working/associative memory. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Author Keywords: Alzheimer's Disease Brain Function Cognitive Function Cohort Studies Cross Sectional Studies Magnetic Resonance Imaging Memory MRI Neurological Disorders Small Vessel Disease Subjective Cognitive Decline Subjective Cognitive Impairment White Matter Disease White Matter Hyperintensities

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• ISSN:
  0885-6230
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  6
• NIOSHTIC Number:
  nn:20067761
• Citation:
  Int J Geriatr Psychiatry 2023 Jun; 38(6):e5948
• Contact Point Address:
  Arjun V. Masurkar, Center for Cognitive Neurology, Department of Neurology, NYU Grossman School of Medicine, New York, New York
• Email:
  arjun.masurkar@nyulangone.org
• Federal Fiscal Year:
  2023
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20220701
• Source Full Name:
  International Journal of Geriatric Psychiatry
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0bb97db88b62b4d8d4530e578c045709192783e86917dc692eace688cd9ac17c8717c53cdbad5df8cd502f5351831f5aa34b36904eea73305ace675f45cba8a
• Download URL:
  https://stacks.cdc.gov/view/cdc/230022/cdc_230022_DS1.pdf
• File Type:
  [PDF - 319.37 KB ]