Plasma Proteins Related to Inflammatory Diet Predict Future Cognitive Impairment

Details

• Personal Author:
  An Y ; Ballantyne CM ; Butler L ; Daya GN ; Duggan MR ; Ferrucci L ; Hayden KM ; Liu L ; Moaddel R ; Moghekar A ; Natale G ; Peng Z ; Rapp SR ; Rebholz CM ; Resnick SM ; Shadyab AH ; Snetselaar L ; Sullivan K ; Walker KA
• Description:
  Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer's disease (AD) pathology (Aß42/40) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Cohort Studies Immune System Nervous System Occupational Health Safety
• Keywords:
  Cognitive Function Cohort Studies Dietary Effects Immune System Neuropathology Nutrition Proteins
• ISSN:
  1359-4184
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  California ; Iowa ; Maryland ; Mississippi ; New York ; North Carolina ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 9 ; Pennsylvania ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  4
• NIOSHTIC Number:
  nn:20067743
• Citation:
  Mol Psychiatry 2023 Apr; 28(4):1599-1609
• Contact Point Address:
  Keenan A. Walker, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA
• Email:
  keenan.walker@nih.gov
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  True
• Source Full Name:
  Molecular Psychiatry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c8a14d099555a8cc4bd4ae69284ab360434f3f903429600629747b079683a78310081aecd32653df6cf93485c468b96af604bcb595b645bd4acc344be034b665
• Download URL:
  https://stacks.cdc.gov/view/cdc/230004/cdc_230004_DS1.pdf
• File Type:
  [PDF - 2.69 MB ]