Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC)

Details

• Personal Author:
  Church, Timothy R. ; Drake CG ; Folsom AR ; Joshu C ; Linabery AM ; Lutsey PL ; Nelson HH ; Platz EA ; Prizment AE ; Selvin E
• Description:
  Background: Serum beta-2 microglobulin (B2M), a major histocompatibility complex class I molecule that is a biomarker of kidney filtration and increased cell turnover, is elevated at the time of diagnosis in hematological and some solid cancers. However, serum B2M was not examined prospectively as a marker for cancer risk. We hypothesized that in a population without a prior cancer diagnosis, serum B2M is associated with risk of cancer (n = 2,436), including colorectal (n = 255), lung (n = 298), breast (n = 424), and prostate (n = 524) cancers, and hematological (n = 176) malignancies. Methods: The analytical cohort (n = 12,300) was followed for incident cancers from 1990 through 2006. B2M (range, 0.9-57.8 mg/L) was measured in stored serum collected in 1990-1992. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals for cancer incidence and mortality in relation to quartiles of B2M. Results: Adjusting for age, sex, race, center, education, body mass index, smoking, aspirin, and hormone therapy (in women) and comparing highest to lowest B2M quartiles, HRs were 1.25 (1.06-1.47; Ptrend = 0.002) for total cancer risk and 2.21 (1.32-3.70; Ptrend=0.001) for colorectal cancer risk, with similar HRs for colon and rectal cancers. These associations remained after adjustment for an inflammatory biomarker, C-reactive protein, and after excluding the first three years of follow-up. Significant associations were also observed for mortality from total, lung, and hematological cancers. Conclusions: These findings provide the first evidence that higher serum B2M is associated with increased colorectal cancer risk. Impact: This study supports B2M as a potential biomarker for colorectal cancer risk. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Immune System Neoplasms Occupational Health Safety
• Keywords:
  Cancer Rates Cohort Studies Colorectal Cancer Genetic Factors Immune System Proteins
• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Minnesota ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  4
• NIOSHTIC Number:
  nn:20064564
• Citation:
  Cancer Epidemiol Biomark Prev 2016 Apr; 25(4):657-664
• Contact Point Address:
  Anna E. Prizment, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 South 2nd Street, Ste 300, Minneapolis, MN 55454
• Email:
  prizm001@umn.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:de66e0fc96919a592ccad6cc1700c7048ac8300ed8369bee7fc758491d1d417497058587caa13d05dffb510ce577adead0a024428db1ec467951783009f24fd2
• Download URL:
  https://stacks.cdc.gov/view/cdc/223003/cdc_223003_DS1.pdf
• File Type:
  [PDF - 192.69 KB ]