Editorial: Additive or Synergistic Impacts of Sleep, Circadian Rhythm Disturbances and Other Modifiable Risk Factors on Established and Novel Plasma Biomarkers of Alzheimer’s Disease Pathology

Details

• Personal Author:
  Ayappa I ; Bubu OM ; Kam K ; Parekh A
• Description:
  Overall, this special topic section presents the evidence of the associations between sleepiness and neuronal injury markers, with sleepiness and amyloid levels showing possible synergistic effects on p-tau/Aß42. It also presents evidence-using WT mice models induced with chronic fragmentation-demonstrating that under conditions of sleep fragmentation, hypocretin/orexin is essential for the accumulation of amyloid-ß. Moreover, it presents evidence showing that OSA and APOE-e4 are interactively associated with WHM in Black/African Americans. More importantly, the review highlights the need for more studies that provide a more comprehensive understanding of the mechanisms by which specific neurodegenerative diseases and pathogenic proteins affect the circadian rhythm and sleep system, as well as the interactions linking sleep and the circadian rhythm system with potential causal mechanisms resulting in synergistic exposure effects on AD progression. This topic remains an open and active area of research because of the continued need to understand both how and when to modify identifiable risk factors, not only across the general population but also with appropriate care and precision among minoritized populations who may suffer from a combination of under-characterization and under-appreciation in terms of AD risk. [Description provided by NIOSH]
• Subjects:
  Biomarkers Circadian Rhythm Occupational Health Pathology Safety Sleep
• Keywords:
  Circadian Rhythms Neurological Diseases Proteins
• ISSN:
  1663-4365
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• NIOSHTIC Number:
  nn:20067703
• Citation:
  Front Aging Neurosci 2023 Mar; 15:1168062
• Contact Point Address:
  Omonigho M. Bubu, Department of Psychiatry, Healthy Brain Aging and Sleep Center, New York University Grossman School of Medicine, New York, NY, United States
• Email:
  omonigho.bubu@nyulangone.org
• Federal Fiscal Year:
  2023
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20210701
• Source Full Name:
  Frontiers in Aging Neuroscience
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:090bbebc1a212b7038e353b09a6e080dfac778a992f813b2439d5ea98faa9f43418fbafdce727e7c15671fe22183626b2c20beedc2e2e60b5b09e55f1bddc7d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/229966/cdc_229966_DS1.pdf
• File Type:
  [PDF - 122.10 KB ]