Mycophenolic Derivatives from Eupenicilliumparvum

Habib, Eman; León, Francisco; Bauer, John D.; Hill, Robert A.; Carvalho, Paulo; Cutler, Horace G.; Cutler, Stephen J.

doi:10.1021/np8003497

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Mycophenolic Derivatives from Eupenicilliumparvum

Published Date:

Nov 07 2008

Publisher's site:

http://dx.doi.org/10.1021/np8003497 New Site Icon

Source:

J Nat Prod. 2008; 71(11):1915-1918.

[PDF - 237.07 KB]

Details:

Personal Authors:

Habib, Eman ; León, Francisco ; Bauer, John D. ; Hill, Robert A. ; Carvalho, Paulo ; ... More ▼

Keywords:

[+]

Description:

A new compound, euparvic acid (1, C(14)H(16)O(6)), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1 was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5 was determined via MPA ester derivatization.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

5 U01 CI000211/CI/NCPDCID CDC HHS/United States
C06 RR-14503-01/RR/NCRR NIH HHS/United States

Supporting Files:

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