Mycophenolic Derivatives from Eupenicilliumparvum

Details

• Alternative Title:
  J Nat Prod
• Personal Author:
  Habib, Eman ; León, Francisco ; Bauer, John D. ; Hill, Robert A. ; Carvalho, Paulo ; Cutler, Horace G. ; Cutler, Stephen J.
• Description:
  A new compound, euparvic acid (1, C(14)H(16)O(6)), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1 was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5 was determined via MPA ester derivatization.
• Subjects:
  Anti-Bacterial Agents Aspergillus Fumigatus Candida Albicans Cryptococcus Neoformans Crystallography, X-Ray Escherichia Coli Eupenicillium Methicillin-Resistant Staphylococcus Aureus Microbial Sensitivity Tests Molecular Conformation Molecular Structure Mycophenolic Acid Note Pseudomonas Aeruginosa

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• Source:
  J Nat Prod. 2008; 71(11):1915-1918.
• Document Type:
  Journal Article
• Funding:
  5 U01 CI000211/CI/NCPDCID CDC HHS/United States ; C06 RR-14503-01/RR/NCRR NIH HHS/United States
• Volume:
  71
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:22f37bd7ecff435ba07bcb1059c329aadb9128a2491c991b58096cc9bbb0ffcd
• Download URL:
  https://stacks.cdc.gov/view/cdc/22994/cdc_22994_DS1.pdf
• File Type:
  [PDF - 237.07 KB ]