Details:

Alternative Title:
Clin Interv Aging
Personal Author:
Hagerman, Randi J ; Hall, Deborah A ; Coffey, Sarah ; Leehey, Maureen ; Bourgeois, James ; ... More +
Hagerman, Randi J ; Hall, Deborah A ; Coffey, Sarah ; Leehey, Maureen ; Bourgeois, James ; Gould, John ; Zhang, Lin ; Seritan, Andreea ; Berry-Kravis, Elizabeth ; Olichney, John ; Miller, Joshua W ; Fong, Amy L ; Carpenter, Randall ; Bodine, Cathy ; Gane, Louise W ; Rainin, Edgar ; Hagerman, Hillary ; Hagerman, Paul J Less -
Description:
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurological disorder that affects older adult carriers, predominantly males, of premutation alleles (55 to 200 CGG repeats) of the fragile X (FMR1) gene. Principal features of FXTAS are intention tremor, ataxia, parkinsonism, cognitive decline, and peripheral neuropathy; ancillary features include, autonomic dysfunction, and psychiatric symptoms of anxiety, depression, and disinhibition. Although controlled trials have not been carried out in individuals with FXTAS, there is a significant amount of anecdotal information regarding various treatment modalities. Moreover, there exists a great deal of evidence regarding the efficacy of various medications for treatment of other disorders (eg, Alzheimer disease) that have substantial phenotypic overlap with FXTAS. The current review summarizes what is currently known regarding the symptomatic treatment, or potential for treatment, of FXTAS.
Subject:
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Aged
Aged, 80 And Over
Ataxia
Dementia
Fragile X Mental Retardation Protein
Fragile X Syndrome
Heredodegenerative Disorders, Nervous System
Heterozygote
Humans
Male
Middle Aged
Neurodegeneration
Parkinsonian Disorders
Parkinsonism
Review
Tremor

Source:
Clin Interv Aging. 2008; 3(2):251-262.
Document Type:
Journal Article
Funding:
HD02274/HD/NICHD NIH HHS/United States ; HD036071/HD/NICHD NIH HHS/United States ; K23 NS052487/NS/NINDS NIH HHS/United States ; NS044299/NS/NINDS NIH HHS/United States ; NS052487/NS/NINDS NIH HHS/United States ; ... More +
HD02274/HD/NICHD NIH HHS/United States ; HD036071/HD/NICHD NIH HHS/United States ; K23 NS052487/NS/NINDS NIH HHS/United States ; NS044299/NS/NINDS NIH HHS/United States ; NS052487/NS/NINDS NIH HHS/United States ; RL1AG032115/AG/NIA NIH HHS/United States ; U10/CCU925123/CC/ODCDC CDC HHS/United States ; UL1RR024922/RR/NCRR NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:79d48ed3ae923b14ccc98bb6dd9acc85ad808db47a58c873ed0f74d9d251abe7
File Type:

Supporting Files

• 	cia-0302-251.nxml	txt
  	license.txt	txt

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