Details:

Alternative Title:
Arch Environ Contam Toxicol
Personal Author:
Que Hee, Shane S. ; Zainal, Hanaa
Que Hee, Shane S. ; Zainal, Hanaa Less -
Description:
The aim of this study was to measure permeation of the herbicide dichlobenil in Casoron 4G through disposable and chemically protective nitrile gloves using an American Society for Testing and Materials-type permeation cell and a closed-loop system employing two different solvents (hexane and water) and two different challenge situations (aqueous emulsion and solid formulation). Capillary gas chromatography-mass spectrometry was used for quantification purposes. The chemically protective glove did not allow any permeation up to 8 h for the solid-formulation and water-collection challenges, but permeation was detected in all other challenges. The disposable glove allowed the most permeation, and the solid-formulation challenge with water collection necessitated that a dichlobenil equivalent be calculated because of the presence of its hydrolysis degradation product 2,6-dichlorobenzamide. Permeation from the solid formulation was detectable by hexane collection for both the disposable and chemically protective gloves and by water collection for the disposable glove. It was concluded that hexane-solvent collection was not valid for the disposable glove at 4 and 8 h of permeation in the solid Casoron challenge or for the aqueous emulsion challenge at 8 h relative to the water-collection solvent data. The hexane-solvent collection for the chemically protective glove was valid for the 8-h solid-formulation challenge but not for the 8-h aqueous-solution challenge. All water-solvent collections were valid; however, dichlobenil usually permeated the gloves.
Subjects:
[+]
Article Benzamides Disposable Equipment Drug Stability Gas Chromatography-Mass Spectrometry Gloves, Protective Herbicides Hexanes Hydrolysis Nitriles Permeability Solubility Solvents Time Factors Water
Source:
Arch Environ Contam Toxicol. 58(2):249-254.
Pubmed ID:
19855916
Pubmed Central ID:
PMC2816820
Document Type:
Journal Article
Funding:
OH03754/OH/NIOSH CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dbcf574c24e2686b8ff9f464526b7c28c56d881273cc9944c7c4ce1b9e12f06f
Download URL:
https://stacks.cdc.gov/view/cdc/22924/cdc_22924_DS1.pdf
File Type:

Supporting Files

• 	244_2009_Article_9407.nxml	txt
  	license.txt	txt

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