The Inflammasome in Host Defense

Details

• Alternative Title:
  Sensors (Basel)
• Personal Author:
  Chen, Gang ; Pedra, Joao H.F.
• Description:
  Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes.
• Subjects:
  Animals Cytokines Humans Immunity, Innate Inflammasome Inflammasomes Inflammation Mediators Innate Immunity Models, Immunological Nod-like Receptors Nod Signaling Adaptor Proteins Review

  More +
• Source:
  Sensors (Basel). 2010; 10(1):97-111.
• Pubmed ID:
  22315529
• Pubmed Central ID:
  PMC3270830
• Document Type:
  Journal Article
• Funding:
  K01 CK000101/CK/NCEZID CDC HHS/United States
• Volume:
  10
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:de0cc54431449c0ae902ab5d2692307bb585b707b3c85450b80e508f6fdeb6d0
• Download URL:
  https://stacks.cdc.gov/view/cdc/22771/cdc_22771_DS1.pdf
• File Type:
  [PDF - 718.95 KB ]