Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/ehp.1104671
Personal Author:
Van Zutphen, Alissa R. ; Lin, Shao ; Fletcher, Barbara A. ; Hwang, Syni-An
Van Zutphen, Alissa R. ; Lin, Shao ; Fletcher, Barbara A. ; Hwang, Syni-An Less -
Description:
Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited.|To determine whether pregnancies are potentially vulnerable to the weather extremes anticipated with climate change, we evaluated the relationship between extreme summer temperature and the occurrence of birth defects.|We performed a population-based case-control study by linking the New York State Congenital Malformations Registry to birth certificates for the years 1992-2006. We selected nonmalformed infants from a 10% random sample of live births as controls. We assigned meteorologic data based on maternal residence at birth, summarized universal apparent temperature (UAT; degrees Fahrenheit) across the critical period of embryogenesis, and estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) with multivariable logistic regression, controlling for confounders available on the birth certificate.|Among 6,422 cases and 59,328 controls that shared at least 1 week of the critical period in summer, a 5-degree increase in mean daily minimum UAT was significantly associated with congenital cataracts (aOR = 1.51; 95% CI: 1.14, 1.99). Congenital cataracts were significantly associated with all ambient temperature indicators as well: heat wave, number of heat waves, and number of days above the 90th percentile. Inconsistent associations with a subset of temperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/microphthalmia and gastroschisis (negative).|We found positive and consistent associations between multiple heat indicators during the relevant developmental window and congenital cataracts which should be confirmed with other data sources.
Subject:
[+]
Adult
Case-Control Studies
Congenital Abnormalities
Female
Hot Temperature
Humans
Infant
Infant, Newborn
Logistic Models
Male
Risk Factors
Seasons
Young Adult

Source:
Environ Health Perspect. 2012; 120(10):1443-1449.
Pubmed ID:
23031822
Pubmed Central ID:
PMC3491926
Document Type:
Journal Article
Funding:
1U38EH000184-05/EH/NCEH CDC HHS/United States ; 5U01EH000396-02/EH/NCEH CDC HHS/United States
1U38EH000184-05/EH/NCEH CDC HHS/United States ; 5U01EH000396-02/EH/NCEH CDC HHS/United States Less -
Place as Subject:
New York
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f35c4b40c0965cda07d6db3d46d1f5a386ff77030ae1e22427546d54daa539b6
File Type:

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