Temporal Association of Prostate Cancer Incidence with World Trade Center Rescue/Recovery Work

Details

• Personal Author:
  Boffetta P ; Brackbill RM ; Cone, James E. ; Dasaro CR ; Farfel MR ; Goldfarb DG ; Hall CB ; Kahn AR ; Kristjansson D ; Li J ; Prezant DJ ; Qiao B ; Schymura MJ ; Shapiro M ; Todd AC ; Webber MP ; Yung J ; Zeig-Owens R
• Description:
  Background: The World Trade Center (WTC) attacks on 11 September 2001 created a hazardous environment with known and suspected carcinogens. Previous studies have identified an increased risk of prostate cancer in responder cohorts compared with the general male population. Objectives: To estimate the length of time to prostate cancer among WTC rescue/recovery workers by determining specific time periods during which the risk was significantly elevated. Methods: Person-time accruals began 6 months after enrollment into a WTC cohort and ended at death or 12/31/2015. Cancer data were obtained through linkages with 13 state cancer registries. New York State was the comparison population. We used Poisson regression to estimate hazard ratios and 95% CIs; change points in rate ratios were estimated using profile likelihood. Results: The analytic cohort included 54 394 male rescue/recovery workers. We observed 1120 incident prostate cancer cases. During 2002-2006, no association with WTC exposure was detected. Beginning in 2007, a 24% increased risk (HR: 1.24, 95%CI 1.16 to 1.32) was observed among WTC rescue/recovery workers when compared with New York State. Comparing those who arrived earliest at the disaster site on the morning of 11 September 2001 or any time on 12 September 2001 to those who first arrived later, we observed a positive, monotonic, dose-response association in the early (2002-2006) and late (2007-2015) periods. Conclusions: Risk of prostate cancer was significantly elevated beginning in 2007 in the WTC combined rescue/ recovery cohort. While unique exposures at the disaster site might have contributed to the observed effect, screening practices including routine prostate specific antigen screening cannot be discounted. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cohort Studies Emergency Responders Environmental Exposure Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cancer Rates Cohort Studies Disaster Recovery Disaster Response Environmental Exposure First Responders Prostate Cancer Rescue Workers Terrorism World Trade Center WTC

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  78
• Issue:
  10
• NIOSHTIC Number:
  nn:20063477
• Citation:
  Occup Environ Med 2021 Oct; 78(10):699-706
• Contact Point Address:
  Dr Charles B Hall, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461
• Email:
  charles.hall@einsteinmed.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  Albert Einstein College of Medicine, Inc., Bronx, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:276495e949edc58fe7e8f987e26524ac3fccdf5ee3af335b3d4f91208b0a89a720f82f49419f540f8d8573b3a798d42a94719883b981db7c1910ae8ae3c8d316
• Download URL:
  https://stacks.cdc.gov/view/cdc/226537/cdc_226537_DS1.pdf
• File Type:
  [PDF - 1.40 MB ]