Discriminatory Circulating Peptides from Different Inhalation Exposures – Biomarker and Cerebrovascular Implications

Details

• Personal Author:
  Ottens A
• Description:
  Mechanisms underlying the diversity of systemic health impacts following different inhalation exposures may, in part, relate to a complex make-up of inducible peptides released into circulation. With developed mass spectrometric methods, we have revealed an induced sero-peptidome following pulmonary exposure. Distinct signatures are revealed in response to carbon nanomaterials, ozone, and secondhand smoke exposures, with both dose-dependent and -independent responses. The diversity in sero-peptidome response offered advantages for biomarker model development, providing the ability to build selective models based on the nature of exposure. Studies also show altered cerebrovascular permeability based on the inhalation exposure and the translocation of induced peptides into the central nervous system. Furthermore, behavioral deficits in juvenile animals exposed to secondhand smoke were correlated with inhalation-induced peptides. Novel software being developed in our laboratory provides improved sero-peptidome characterization and reflects an associated with an immune/inflammatory response. These findings provide novel perspectives on the origins of systemic toxicity arising indirectly from pulmonary exposures to inhaled particulates. [Description provided by NIOSH]
• Subjects:
  Biomarkers Immune System Occupational Health Ozone Particulate Matter Respiratory System Safety Toxicology
• Keywords:
  Dose Response Health Effects Immune Reaction Inhalation Studies Nanomaterials Particulates Peptides Secondhand Smoke
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 6 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• Issue:
  1
• NIOSHTIC Number:
  nn:20063337
• Citation:
  Toxicologist 2017 Mar; 156(1):321
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of New Mexico Health Sciences Center, Albuquerque, New Mexico
• Peer Reviewed:
  False
• Start Date:
  20150930
• Source Full Name:
  The Toxicologist. Society of Toxicology 56th Annual Meeting and ToxExpo, March 12-16, 2017, Baltimore, Maryland
• End Date:
  20190929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cd9b15759408b4710349aa5c6dc24b01c8ceb69d098ab73cbe0bdb31b07e26fc5d516a9a73fde792e3b8df435002696d180d472f39c31348e94928a7a5cd07e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/226416/cdc_226416_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]