The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System – Comparison of CORESTA Flow Rates to More Realistic Flow Rates

Details

• Personal Author:
  Floyd E ; Greenlee S ; Oni T ; Queimado L ; Sadhasivam B
• Description:
  Many types of electronic cigarettes (ECs) are currently in use, but the default flow rate used to simulate puffing is centered on tobacco cigarette flow rates. CORESTA offers several methods and technical guides for evaluation of ECs but there are few puffing topography studies focusing on sub-ohm ECs; differences between real-world usage and that found in the literature appear large. This study focuses on how power and flow rate affect the nicotine yield of a sub-ohm EC. A puffing system (Puff3rd) has been designed and used to produce and collect EC aerosol. Nicotine yield was measured by GC-MS at three power levels and four flow rates. Data analysis was conducted in SAS using the MIXED procedure. Power, flow rate, and their interaction were all significant predictors of nicotine yield. Nicotine yield increased with both the vaping power and the puff flow rate with significant interaction of the two. Findings indicate that using the current CORESTA flow rate (1100 mL/min) to evaluate third-generation ECs underestimates nicotine yield and likely overestimates pyrolysis products. Real users are expected to have 2-3× the nicotine dose measured at 1100 mL/min, which could confound epidemiological studies seeking to link nicotine delivery to product satisfaction and acceptability. [Description provided by NIOSH]
• Subjects:
  Aerosols Electrical Equipment And Supplies Nicotine Occupational Health Pyrolysis Safety Smokers Solvents Tobacco Products
• Keywords:
  Author Keywords: Electronic Cigarettes Cigarette Smoke Cigarette Smoking CORESTA Electrical Resistance Electronic Devices Flow Rate Gas Chromatography Mass Spectrometry Nicotine Yield PMTAs Power Settings Vapors Vapor Volume

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Oklahoma ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  14
• NIOSHTIC Number:
  nn:20063149
• Citation:
  Int J Environ Res Public Health 2021 Jul; 18(14):7535
• Contact Point Address:
  Evan Floyd, Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
• Email:
  evan-floyd@ouhsc.edu
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Oklahoma Health Sciences Center
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:281969c3eb1f83a0ef0dce52cae2436a68cbb0b74609b04ac47a6012093482e5b36af139e1029c7953fd319c166bd2064b8e363b8c068b318b3b2dc921f8bb8c
• Download URL:
  https://stacks.cdc.gov/view/cdc/226266/cdc_226266_DS1.pdf
• File Type:
  [PDF - 2.42 MB ]