PTSD Is Associated with Accelerated Transcriptional Aging in World Trade Center Responders

Details

• Personal Author:
  Bromet E ; Clouston S ; Jonas K ; Kotov R ; Kuan P-F ; Luft BJ ; Ren X ; Yang X
• Description:
  Posttraumatic stress disorder (PTSD) is associated with shortened lifespan and healthspan, which suggests accelerated aging. Emerging evidence suggests that methylation age may be accelerated in PTSD. It is important to examine whether transcriptional age is also accelerated because transcriptome is highly dynamic, associated with age-related outcomes, and may offer greater insight into the premature aging in PTSD. This study is the first reported investigation of the relationship between transcriptional age and PTSD. Using RNA-Seq data from our previous study on 324 World Trade Center responders (201 never had PTSD, 81 with current PTSD, and 42 with past PTSD), as well as a transcriptional age calculator (RNAAgeCalc) recently developed by our group, we found that responders with current PTSD, compared with responders without a PTSD diagnosis, showed accelerated transcriptional aging (p = 0.0077) after adjustment for chronological age and race. We compared our results to the epigenetic aging results computed from several epigenetic clock calculators on matching DNA methylation data. GrimAge methylation age acceleration was also associated with PTSD diagnosis (p = 0.0097), and the results remained significant after adjustment for the proportions of immune cell types. PhenoAge, Hannum, and Horvath methylation age acceleration were not reliably related to PTSD. Both epigenetic and transcriptional aging may provide biological insights into the mechanisms underpinning aging in PTSD. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Emergency Responders Genetics Longevity Mental Disorders Mental Health Methanol Occupational Health Safety September 11 Terrorist Attacks

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• Keywords:
  Age Factors Biochemical Markers Emergency Responders Gene Expression Humans Lifespan Mental Disorders Methyl Compounds Physiology Post-traumatic Stress Disorder Psychological Disorders PTSD Rescue Workers Ribonucleic Acids RNA World Trade Center WTC

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• ISSN:
  2158-3188
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20063084
• Citation:
  Transl Psychiatry 2021 May; 11:311
• Contact Point Address:
  Benjamin J Luft, Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA
• Email:
  Benjamin.luft@stonybrookmedicine.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Translational Psychiatry
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5a1ad04dfb8e242ca768438dee19ad6c051ba1db67b6cc365b39abcc5d5ae1941c77227a16429a798e2c3d58337a56805336421b9ad05fa9f5de3b90b8c5407a
• Download URL:
  https://stacks.cdc.gov/view/cdc/226211/cdc_226211_DS1.pdf
• File Type:
  [PDF - 882.86 KB ]